国际眼科杂志2025，Vol.25Issue(5)：714-717,4.DOI:10.3980/j.issn.1672-5123.2025.5.04
不同分期DR患者视网膜神经纤维层厚度和视网膜厚度及血流密度的变化
Changes of retinal nerve fiber layer thickness,retinal thickness and blood flow density in different stages of diabetic retinopathy patients
摘要
Abstract
AIM:To investigate the changes of retinal nerve fiber layer(RNFL)thickness,retinal thickness and blood flow density in different stages of diabetic retinopathy(DR)patients based on optical coherence tomography angiography(OCTA). METHODS:A retrospective analysis was conducted on 382 patients(382 eyes)diagnosed with DR in our hospital from February 2023 to February 2024.According to the staging criteria,the patients were divided into mild group(n=121),moderate group(n=133),severe group(n=72),and proliferative group(n=56).The general clinical data of the four groups of patients was compared;OCTA was used to scan and collect data from all patients,and the RNFL thickness,retinal thickness,and blood flow density were compared among the four groups of patients. RESULTS:There was no statistically significant difference in age,gender,hypertension,chronic kidney disease,and random blood glucose among patients in the mild,moderate,severe,and proliferative groups(all P＞0.05).As the stage of DR worsened,the duration of the disease gradually prolonged(P＜0.05).The thickness of the RNFL(superior,inferior,temporal,nasal,and average thickness)and retinal thickness significantly increased with the severity of DR(all P＜0.001);however,there was no statistically significant difference in inferior RNFL thickness between the moderate and mild groups(P＞0.05).The blood flow density in the superficial and deep retinal layers,as well as in the choroidal capillary layer,significantly decreased with the progression of DR(all P＜0.05).Nevertheless,there was no statistically significant difference in superficial retinal blood flow density between the moderate and severe groups(P＞0.05). CONCLUSION:OCTA can accurately observe the changes in RNFL thickness,retinal thickness,and blood flow density in patients with DR at different stages,which can serve as sensitive indicators for monitoring DR progression.关键词
光相干断层扫描血管成像技术/糖尿病视网膜病变(DR)/视网膜神经纤维层厚度/视网膜厚度/血流密度Key words
optical coherence tomography angiography/diabetic retinopathy(DR)/retinal nerve fiber layer thickness/retinal thickness/blood flow density引用本文复制引用
张树军,黄帅,李佳佳,裴松波,李钰泓..不同分期DR患者视网膜神经纤维层厚度和视网膜厚度及血流密度的变化[J].国际眼科杂志,2025,25(5):714-717,4.基金项目
河北省医学科学研究课题(No.20241204) Medical Science Research Project of Hebei Province(No.20241204) （No.20241204）
