国际眼科杂志2025，Vol.25Issue(5)：725-733,9.DOI:10.3980/j.issn.1672-5123.2025.5.06
房水中MCP-1水平与视网膜静脉阻塞继发黄斑水肿复发及黄斑区微循环的关系
Relationship between the expression of monocyte chemoattractant protein-1 in aqueous humor and the recurrence and microcirculation of macular edema secondary to retinal vein occlusion
摘要
Abstract
AIM:To investigate the relationship between the level of monocyte chemoattractant protein-1(MCP-1)in the aqueous humor and macular microcirculation in patients with macular edema secondary to retinal vein occlusion(RVO-ME). METHODS:A total of 327 patients(327 eyes)with RVO-ME treated in our hospital from July 2022 to July 2024 were selected as the research objects.According to the recurrence or not,they were divided into non-recurrence group(291 cases,291 eyes)and recurrence group(36 cases,36 eyes).The clinical data,macular microcirculation index and MCP-1 level were collected.Unordered multinomial Logistic regression was used to analyze the effect of MCP-1 on RVO-ME recurrence after excluding the influence of other factors.Cubic spline was used to analyze the dose-response relationship between macular microcirculation indexes and MCP-1 expression level and RVO-ME recurrence.Multiple linear regression was used to analyze the relationship between macular microcirculation parameters and MCP-1 expression level,and the difference of MCP-1 expression level in recurrence under different macular microcirculation parameters was analyzed.Bootstrap method was used to test the mediating effect of macular microcirculation indexes on MCP-1 expression level and RVO-ME recurrence. RESULTS:The course of ME,the incidence of vitreomacular traction(VMT),the incidence of fibrous membrane epiretinal membrane(ERM),best corrected visual acuity(BCVA),hyperreflective foci in the inner and outer retinal layers(HRF),the frequency and dose of anti-vascular endothelial growth factor(VEGF)injection in the recurrence group were significantly higher than those in the non-recurrence group(all P＜0.05).The external limiting membrane(ELM)integrity and ellipsoid zone(EZ)integrity in the recurrence group were significantly worse than those in the non-recurrence group(all P＜0.05).The central foveal thickness(CFT),central macular thickness(CMT),superficial capillary plexus(SCP)vascular density,deep capillary plexus(DCP)vascular density and MCP-1 in the recurrence group were higher than those in the non-recurrence group(all P＜0.05),and the foveal avascular zone(FAZ)area was lower than that in the non-recurrence group(P＜0.05).Logistic analysis showed that MCP-1 was a risk factor for RVO-ME recurrence before and after adjusting for confounding factors.There was a significant non-linear dose-response relationship between macular microcirculation indexes and MCP-1 expression and the risk of RVO-ME recurrence(non-linear test,all P＜0.001).The vascular density of CFT,CMT,SCP and DCP was positively correlated with the expression level of MCP-1(all P＜0.05),while the FAZ was negatively correlated with MCP-1 expression level(P＜0.05).With the increase of vessel density in CFT,CMT,SCP and DCP,and the decrease of FAZ,the expression level of MCP-1 increased,and the risk of RVO-ME recurrence showed an upward trend.The proportion of MCP-1 in Q3(＞28.47 pg/mL)group was the highest(P＜0.05).Macular microcirculation parameters play a mediating effect between MCP-1 expression level and RVO-ME recurrence. CONCLUSION:The level of MCP-1 in aqueous humor is positively correlated with RVO-ME recurrence,and it is closely related to macular microcirculation.Macular microcirculation has a mediating effect between MCP-1 level and RVO-ME recurrence.关键词
单核细胞趋化蛋白-1(MCP-1)/视网膜静脉阻塞/继发黄斑水肿/黄斑区微循环Key words
monocyte chemoattractant protein-1(MCP-1)/retinal vein occlusion/secondary macular edema/microcirculation of macular area引用本文复制引用
冷炫,李杰,区健滨..房水中MCP-1水平与视网膜静脉阻塞继发黄斑水肿复发及黄斑区微循环的关系[J].国际眼科杂志,2025,25(5):725-733,9.基金项目
2023年度广东省医学科研基金立项项目(No.B2023217) Guangdong Medical Research Foundation in 2023(No.B2023217) （No.B2023217）
