国际眼科杂志2025，Vol.25Issue(5)：754-759,6.DOI:10.3980/j.issn.1672-5123.2025.5.11
息肉状脉络膜血管病变相关分子生物标志物的研究进展
Research progress on molecular biomarkers related to polypoid choroidal vasculopathy
摘要
Abstract
Polypoid choroidal vasculopathy(PCV)is associated with poor visual prognosis in its natural course and is more prevalent in Asian populations.Despite advancements in optical coherence tomography(OCT)and OCT angiography(OCTA)that have significantly improved morphological diagnostic capabilities,imaging biomarkers are limited by temporal resolution constraints and fail to elucidate molecular mechanisms underlying vascular angiogenesis,inflammation,genetic factors,and extracellular matrix(ECM)remodeling.This review synthesizes current research on molecular biomarkers associated with PCV,focusing on its core pathological mechanisms.These biomarkers provide crucial insights into disease pathogenesis to inform precision prevention,dynamic disease monitoring,and therapeutic response prediction.Furthermore,this article proposes the integration of multi-omics data(genomics,proteomics,and radiomics)to establish a multimodal hierarchical diagnostic-therapeutic model.This framework will guide risk stratification,real-time disease assessment,and personalized treatment strategies,advancing the development of a precision medicine framework for PCV management.关键词
息肉状脉络膜血管病变/血管生成/炎症/遗传/细胞外基质/分子生物标志物Key words
polypoid choroidal vasculopathy/angiogenesis/inflammation/heredity/extracellular matrix/molecular biomarker引用本文复制引用
刘菁菁,肖阳艳,华夏..息肉状脉络膜血管病变相关分子生物标志物的研究进展[J].国际眼科杂志,2025,25(5):754-759,6.基金项目
国家自然科学基金面上项目(No.82471053) （No.82471053）
天津市科技计划项目(No.22JCZDJC00260) National Natural Science Foundation of China(No.82471053) （No.22JCZDJC00260）
Science and Technology Plan Project of Tianjin(No.22JCZDJC00260) （No.22JCZDJC00260）
