国际眼科杂志2025，Vol.25Issue(5)：797-801,5.DOI:10.3980/j.issn.1672-5123.2025.5.19
蛋白质乳酸化修饰在眼科疾病中的研究进展
Research progress on protein lactylation in ophthalmic diseases
摘要
Abstract
Lactylation,a recently identified post-translational modification of proteins,is induced by lactic acid and can occur at multiple lysine residues in both histone and non-histone proteins.This modification plays a role in disease pathogenesis by affecting transcriptional regulation,mitochondrial metabolism,and immune inflammation.Significant advancements have been made in understanding the mechanisms of lactylation in various ophthalmic diseases,including retinal neovascularization,uveitis,melanoma,and myopia.This paper provides a comprehensive review of the relationship between lactic acid and lactylation,the regulatory mechanisms of lactylation,and the role of lactylation in different ocular diseases.Additionally,it addresses current research limitations and future directions,which is of great significance to elucidate the molecular mechanisms of lactylation in eye diseases and improving the diagnosis and targeted treatment of these conditions.关键词
乳酸/乳酸化/糖酵解/翻译后修饰/眼科疾病Key words
lactic acid/lactylation/glycolysis/post-translational modification/ophthalmic diseases引用本文复制引用
陈洪良,索龙,王乾坤,刘爽..蛋白质乳酸化修饰在眼科疾病中的研究进展[J].国际眼科杂志,2025,25(5):797-801,5.基金项目
宿迁市自然科学基金项目(No.K202312) （No.K202312）
宿迁市第一人民医院科研专项(No.KY202317) （No.KY202317）
南京医科大学科技发展基金项目(No.NMUB20220215) Natural Science Foundation of Suqian(No.K202312) （No.NMUB20220215）
Scientific Research Project of Suqian First Hospital(No.KY202317) （No.KY202317）
Science and Technology Development Foundation of Nanjing Medical University(No.NMUB20220215) （No.NMUB20220215）
