中南医学科学杂志2025，Vol.53Issue(2)：288-291,4.DOI:10.15972/j.cnki.43-1509/r.2025.02.023
血清HDAC2、SMAD7水平与HDCP严重程度及预后关系的分析
Analysis of the relationship between serum HDAC2 and SMAD7 levels and the severity,and prognosis of HDCP
摘要
Abstract
Aim To analyze the levels of serum recombinant histone deacetylase 2(HDAC2),SMA-and MAD-related pro-tein 7(SMAD7)in patients with hypertensive disorder complicating pregnancy(HDCP)and their relationship with disease severity and prognosis.Methods 213 patients with HDCP who visited our hospital were selected as the HDCP group.According to the se-verity of the disease,they were divided into pregnancy induced hypertension group(105 cases),preeclampsia group(64 cases),and severe preeclampsia group(44 cases).According to pregnancy outcomes,there were 45 cases in the poor prognosis group and 168 cases in the good prognosis group.At the same time,197 healthy pregnant women were included as the control group.Enzyme linked immunosorbent assay was used to detect the levels of serum HDAC2 and SMAD7 in each group.Multivariate Logistic regres-sion was applied to analyze the factors influencing adverse pregnancy outcomes in HDCP patients.The predictive efficacy of serum HDAC2 and SMAD7 levels for adverse pregnancy outcomes in HDCP patients was analyzed by using ROC curve analysis.Results The levels of serum HDAC2 and SMAD7 in the HDCP group were lower than those in the control group(P＜0.05),in an order of pregnancy induced hypertension group＞preeclampsia group＞severe preeclampsia group(P＜0.05);The poor prognosis group was lower than the good prognosis group(P＜0.05).The proportion of severe preeclampsia patients in the poor prognosis group was high-er than that in the good prognosis group(P＜0.05).HDAC2,SMAD7 and severe preeclampsia were the influencing factor for adverse pregnancy outcomes in HDCP patients(P＜0.05).The AUC value of predicting adverse pregnancy outcomes in HDCP pa-tients by combining serum HDAC2 and SMAD7 is higher than its individual AUC value.Conclusion The expression levels of HDAC2 and SMAD7 are relatively low in the serum of HDCP patients.HDAC2 and SMAD7 are the influencing factors for adverse pregnancy outcomes in patients with HDCP;The combined predictive power for adverse pregnancy outcomes in HDCP patients is higher than its individual predictive power.关键词
妊娠期高血压疾病/HDAC2/SMAD7/预后Key words
HDCP/HDAC2/SMAD7/prognosis分类
中医学引用本文复制引用
姜海英,张桂欣,宋志慧,左金玲,张哲..血清HDAC2、SMAD7水平与HDCP严重程度及预后关系的分析[J].中南医学科学杂志,2025,53(2):288-291,4.基金项目
河北省2023年度医学科学研究重点课题计划项目(20231751) （20231751）
