临床神经外科杂志2025，Vol.22Issue(2)：158-165,8.DOI:10.3969/j.issn.1672-7770.2025.02.007
多模态神经导航联合术中超声及荧光素钠引导高级别胶质瘤精准切除
Guided precision resection of high-grade gliomas using multimodal neuronavigation integrated with intraoperative ultrasound and sodium fluorescein
摘要
Abstract
Objective To investigate the value of multimodal functional neuronavigation image fusion in conjunction with intraoperative fluorescein sodium and intraoperative ultrasound in high-grade glioma resection.Methods The clinical data of 98 patients treated from January 2018 to February 2024 who underwent resection of high-grade intracranial glioma using multimodal functional neuronavigation and intraoperative ultrasound were collected and randomly divided into observation group and control group by random comparison table method,with 49 cases in each group.The control group was given multimodal functional neuronavigation and intraoperative ultrasound to perform high-grade intracranial glioma resection.The observation group was given multimodal functional neuronavigation and intraoperative ultrasound combined with intraoperative fluorescein sodium to perform high-grade intracranial glioma resection.The postoperative tumor resection extent,improvement of postoperative muscle strength,postoperative complications,new neurological dysfunction and operation time were statistically compared between the two groups.Results Through the summary of the original data,there was no statistical significance in gender,age,tumor location,pathological grade and other data between the observation group and the control group(P＞0.05),and the data were comparable.The results showed that the total tumor resection rate in the observation group(91.84％)was significantly higher than that in the control group(75.51％),and the difference was statistically significant(x2=4.781,P=0.029).The improvement of muscle strength in the observation group was significantly higher than that in the control group(x2=6.498,P=0.011).The incidence of postoperative new dysfunction in the observation group was lower than that in the control group,and the difference was statistically significant(x2=4.346,P=0.037).The incidence of postoperative intracranial infection complication was not statistically significant between the observation group and the control group(x2=1.133,P=0.248),the incidence of pulmonary infection was not statistically significant(x2=0.708,P=0.400),and the incidence of epilepsy was not statistically significant(x2=0.000,P=1.000).The operation time in the observation group was less than that in the control group,and the difference was statistically significant(t=2.621,P=0.010).Conclusions Multimodality functional neuronavigation image fusion technology combined with intraoperative fluorescein sodium and intraoperative ultrasound can clearly distinguish the position relationship between tumor tissue and normal brain tissue,and can achieve the maximum resection of glioma tissue on the basis of protecting important blood vessels,nerves and conduction surgery,obviously reducing the injury of nervous system,reducing postoperative complications and improving the prognosis of patients.关键词
多模态影像融合/神经导航/荧光素钠/术中超声/高级别胶质瘤Key words
multimodal imaging fusion/neuronavigation/fluorescein sodium/intraoperative ultrasound/high grade glioma分类
临床医学引用本文复制引用
王忠,杨蔚然,王飞,宋钰辉,周志彪,张晓军,张瑞剑,韩志桐,赵卫平,杨文博,邢栋,王俊青..多模态神经导航联合术中超声及荧光素钠引导高级别胶质瘤精准切除[J].临床神经外科杂志,2025,22(2):158-165,8.基金项目
内蒙古自治区卫健委科技计划项目(202201059) （202201059）
内蒙古医科大学联合项目(YKD2023LH082) （YKD2023LH082）
内蒙古自治区人民医院院内基金项目(2019YN04) （2019YN04）
内蒙古自治区医师协会临床医学研究和临床新技术推广项目(YSXH2024KYF005) （YSXH2024KYF005）
