棉纺织技术2025，Vol.53Issue(5)：74-79,6.
负载姜黄素的聚琥珀酰亚胺纳米纤维敷料制备及性能研究
Preparation and property research of polysuccinimide nanofibrous dressing loaded with curcumin
摘要
Abstract
In order to prepare new nanofiber dressing,biomaterials polysuccinimide(PSI)was used as the electrospinning material,and curcumin(Cur)was loaded via solution blending electrospinning method to fabricate PSI/Cur nanofiber membranes.The effects of different Cur loading on the surface morphology,infrared structure,mechanical property,pH color changing,antibacterial property,cytotoxicity and drug controlled release of the nanofiber membranes were investigated.The results showed that varying Cur loading had little impact on the fiber morphology and structure.As the Cur loading increased,the tenacity of PSI/Cur nanofiber membranes was decreased,while the antibacterial rate was improved.When the Cur loading was reached 7%,the antibacterial rate was 100%.The biocompatibility initially increased and then declined,the comprehensive performance of the PSI/Cur nanofiber membrane was optimal when Cur loading was 3%.At this loading,antibacterial rate of the membrane was 98.9%,cell survival rate of extract solution was(107.1±8.1)%,which had distinct pH color changing capability.It can be used for wound pH monitoring.It is concluded that the PSI/Cur nanofiber membrane holds promising potential for applications in wound dressing materials.关键词
姜黄素/聚琥珀酰亚胺/纳米纤维/静电纺丝/敷料/缓释Key words
curcumin/polysuccinimide/nanofiber/electrospinning/dressing/controlled release分类
轻工业引用本文复制引用
邱月,郑乐怡,张宝华,金真,张彩丹..负载姜黄素的聚琥珀酰亚胺纳米纤维敷料制备及性能研究[J].棉纺织技术,2025,53(5):74-79,6.基金项目
嘉兴市科技计划项目(2023AD11035) （2023AD11035）
研究生科研与实践创新项目(PSRPIP2024001C) （PSRPIP2024001C）
大学生科技训练项目(SRT8517241329) （SRT8517241329）
