湖南农业大学学报（自然科学版）2025，Vol.51Issue(2)：89-96,8.
偏硅酸型矿泉水对小鼠脏器指数和血清生化指标及肠道菌群结构的影响
Effects of metasilicic acid mineral water on organ index,serum biochemical indexes and intestinal flora structure in mice
摘要
Abstract
A total of 320 ICR mice with body weight of(18±1)g were randomly divided into 4 groups,with 16 replicates in each group(half male and half female)and 5 mice in each replicate.The mice were fed with purified water(Pw),tap water(Tw),mountain spring water(Nw)and metasilicic acid mineral water(Mw),respectively.The mice were fed with maintenance feed.The pre-test period was 7 days and the test period was 90 days.After the test,the heart,liver,spleen,lung,kidney,brain and whole intestine of the mice were collected to determine the organ index.The orbital blood of the mice was collected to determine the serum biochemical indexes,and the cecal contents of the mice were taken to determine the relative abundance of intestinal flora.The effects of metasilicic acid mineral water on organ index,serum biochemical indexes and intestinal flora structure of mice were analyzed.The results showed that the intestinal organ index of mice in Mw group was 12.92±1.33,which was significantly higher than those in Pw and Tw groups.The conctentration of serum homocysteine(HCY)and plasma endothelin(ET)in serum biochemical indexes were(14.21±1.90)μmol/L and(105.63±10.10)ng/L,which were significantly lower than those in the other three groups.The conctentration of high density lipoprotein(HDL)in serum was(0.36±0.04)mmol/L,which was significantly higher than those in Pw and Tw groups.The mass conctentration of serum GLP-2 was(148.80±9.98)ng/L,which was significantly higher than that of Tw group.The Chao1 index of intestinal flora in Mw group was 337.20±21.89,which was significantly higher than that in Tw group.The relative abundance of Actinobacteria in Mw group was(10.20±3.28)%,which was significantly higher than that in Tw group.The relative abundance of Proteobacteria in Mw group was(1.67±0.18)%,which was significantly lower than that in Tw group.The relative abundance of Escherichia_Shigella and Enterococcus in Mw group were(0.38±0.05)%and(0.39±0.05)%,respectively,which were significantly lower than that in Tw group.The relative abundance of Desulfovibrio in Mw group was(0.87±0.06)%,which was significantly lower than that in Nw group.The relative abundance of Lactobacillus in Mw group was(27.64±2.15)%,which was significantly higher than that in Tw group.The relative abundance of Bifidobacterium in Mw group was(2.81±0.34)%,which was significantly higher than those of the other three groups.In summary,during the test period,mice drinking metasilic acid mineral water increased the whole intestinal organ index and serum high-density lipoprotein conctentration,reduced serum homocysteine and plasma endothelin conctentration,increased serum GLP-2 conctentration in mice,and increased the relative abundance of intestinal probiotics and reduced the relative abundance of mass intestinal pathogens.The changes in these indicators suggest that drinking metasilic acid mineral water may have a certain protective effect on the body.关键词
偏硅酸型矿泉水/脏器指数/血清生化指标/肠道菌群/ICR小鼠Key words
metasilic acid mineral water/organ index/serum biochemical indexes/intestinal flora/ICR mice分类
生物科学引用本文复制引用
陈玉章,吴沁,蓝鹏程,杨明鑫,李晓冰,李焰..偏硅酸型矿泉水对小鼠脏器指数和血清生化指标及肠道菌群结构的影响[J].湖南农业大学学报（自然科学版）,2025,51(2):89-96,8.基金项目
福建龙岩梅花山矿泉水有限公司资助项目(2022097) （2022097）
福建龙岩学院博士启动项目(LB2022009) （LB2022009）
2020年福建省高等学校科技创新团队(产业化专项)项目(JYT202012) （产业化专项）
