内科理论与实践2025，Vol.20Issue(1)：38-45,8.DOI:10.16138/j.1673-6087.2025.01.08
中医药改善糖尿病肾脏疾病间质纤维化的作用机制研究现状
Current research status on mechanism of action of traditional Chinese medicine in improving interstitial fi-brosis of diabetes kidney disease
摘要
Abstract
Diabetes kidney disease(DKD)is a chronic kidney disease caused by hyperglycemia,which is one of the common microvascular complications of diabetes.As one of the significant pathological features,interstitial fibrosis is a key factor leading to renal dysfunction.Its pathological evolution involves multiple mechanisms such as metabolic abnormalities,hemodynamic disorders,inflammatory responses,activation of cellular signaling pathways,epigenetic regulation,and cellular autophagy.This article sorted and analyzed the relevant research on the mechanism of action of traditional Chinese medicine(TCM)in improving interstitial fibrosis of DKD through searching multiple databases(Pubmed,Web of Science,CNKI,WANFANG,VIP databases,etc.).Studies have shown that treatment of TCM may delay DKD interstitial fibrosis through its multi-component,multi-target and multi pathway.In the future,with further in-depth research on the pathogenesis of DKD interstitial fibrosis and continuous clarification of the mechanism of action of TCM,TCM is expected to provide more effective strategies for the prevention and treatment of DKD.关键词
糖尿病肾脏疾病/间质纤维化/中医药Key words
Diabetic kidney disease/Interstitial fibrosis/Traditional Chinese medicine分类
临床医学引用本文复制引用
严佳怡,马骏,钟逸斐,张先闻..中医药改善糖尿病肾脏疾病间质纤维化的作用机制研究现状[J].内科理论与实践,2025,20(1):38-45,8.基金项目
国家自然科学基金项目(82274451) （82274451）
上海市"科技创新行动计划"(23Y11921400) （23Y11921400）
