中南医学科学杂志2025，Vol.53Issue(2)：338-340,344,4.DOI:10.15972/j.cnki.43-1509/r.2025.02.036
IgE、IL-4、IL-1 β、FeNO动态水平对小儿支气管哮喘急性发作的疗效评估价值
Evaluation value of IgE,IL-4,IL-1β,and FeNO levels in assessing the efficacy of acute at-tacks of pediatric bronchial asthma
摘要
Abstract
Aim To analyze the evaluation value of immunoglobulin E(IgE),interleukin(IL)-4,IL-1 β,and fractional exhaled nitric oxide(FeNO)levels in assessing the efficacy of acute attacks of pediatric bronchial asthma.Methods 118 children with acute exacerbation of asthma were selected as the research subjects.After implementing individualized treatment plans,they were divided into the control group(89 cases)and the uncontrolled group(29 cases)based on the efficacy.The levels of IgE,IL-4,IL-1β,and FeNO in 118 pediatric patients before and after treatment,as well as between the control group and the uncontrolled group after treatment were compared.Pearson correlation analysis was used to investigate the correlation between IgE,IL-4,IL-1 β,and FeNO indicators.ROC curve analysis was used to evaluate the therapeutic efficacy of IgE,IL-4,IL-1 β,and FeNO in children with asthma.Results After treatment,the levels of IgE,IL-4,IL-1β,and FeNO in 118 asthmatic children were decreased(P＜0.05).The levels of IgE,IL-4,IL-1β,and FeNO in the control group were lower than those in the uncontrolled group(P＜0.05).There was a positive correlation between IgE,IL-4,IL-1β,and FeNO indicators in children with asthma(P＜0.05).The ROC curve results showed that the AUC values of combining IgE,IL-4,IL-1 β,and FeNO in evaluating the clinical efficacy of acute asthma at-tacks in children were higher than those of single index(P＜0.05).Conclusion Dynamic monitoring of IgE,IL-4,IL-1 β,and FeNO can effectively evaluate the efficacy of acute asthma attacks,and combined detection has higher clinical predictive value than the individual indicator detection.关键词
小儿支气管哮喘/急性发作/IgE/IL-4/IL-1β/FeNO/疗效评估Key words
pediatric bronchial asthma/acute attack/IgE/IL-4/IL-1β/FeNO/efficacy evaluation分类
医药卫生引用本文复制引用
刘硕,薛萍,李小琴,张美娟,王晓红..IgE、IL-4、IL-1 β、FeNO动态水平对小儿支气管哮喘急性发作的疗效评估价值[J].中南医学科学杂志,2025,53(2):338-340,344,4.基金项目
山西省基础研究计划面上项目(202303021221215) （202303021221215）
