临床神经外科杂志2025，Vol.22Issue(2)：219-221,225,4.DOI:10.3969/j.issn.1672-7770.2025.02.017
胶质母细胞瘤微环境中巨噬细胞极化影响因素的研究进展
Research progress on factors influencing macrophage polarization in the microenvironment of glioblastoma
摘要
Abstract
Glioblastoma(GBM)is the most aggressive form of primary intracranial malignancy in adults,and its short survival duration is intricately linked to the immunosuppressive effects mediated by the tumor microenvironment.The phenotypic transition of tumor-associated macrophages(TAMs)is pivotal in establishing immunosuppressive milieu and driving the progression of the disease.This paper presents a comprehensive review of pertinent literature and emerging research developments to examine the factors governing macrophage polarization within the GBM microenvironment and the underlying mechanisms involved.关键词
肿瘤相关巨噬细胞/胶质母细胞瘤/肿瘤免疫微环境/巨噬细胞极化/免疫治疗Key words
tumor-associated macrophages/glioblastoma/tumor immune microenvironment/macrophage polarization/immunotherapy分类
临床医学引用本文复制引用
杨晓雄,刘轩辰,张晋伟,吉宏明,王春红..胶质母细胞瘤微环境中巨噬细胞极化影响因素的研究进展[J].临床神经外科杂志,2025,22(2):219-221,225,4.基金项目
山西省基础研究计划项目(202103021224380) （202103021224380）
山西省教育厅2024年度研究生教育创新计划项目(2024SJ177) （2024SJ177）
