中南医学科学杂志2025，Vol.53Issue(2)：365-368,4.DOI:10.15972/j.cnki.43-1509/r.2025.02.043
血清URH、VASH-1、ATG7水平与2型糖尿病肾病患者病情程度及肾功能指标的相关性
Correlation analysis of serum URH,VASH-1,and ATG7 levels with disease severity and re-nal function indicators in patients with type 2 diabetic nephropathy
摘要
Abstract
Aim To investigate the correlation between serum uric acid/high-density lipoprotein cholesterol(URH),vasohib-in-1(VASH-1),and autophagy-related protein 7(ATG7)levels with disease severity and renal function indicators in patients with type 2 diabetic nephropathy(DN).Methods A total of 150 type 2 DN patients were selected and divided into mild(n=39),moderate(n=67),and severe(n=44)groups based on estimated glomerular filtration rate(eGFR).The levels of URH,VASH-1,ATG7,and renal function indicators,as well as blood glucose and lipid levels,were compared among the three groups.Linear correlation analysis was used to analyze the correlation between URH,VASH-1,ATG7,and renal function indicators in DN patients.Results The URH and VASH-1 levels in the severe and moderate groups were higher than those in the mild group,while ATG7 levels were lower(P＜0.05).The URH and VASH-1 levels in the severe group were higher than those in the moderate group,while ATG7 levels were lower(P＜0.05).The ALB levels in the severe and moderate groups were lower than those in the mild group;the ALB levels in the severe group were lower than those in the moderate group(P＜0.05).The BUN,Scr,and UACR levels in the severe and moderate groups were higher than those in the mild group(P＜0.05);the BUN,Scr,and UACR levels in the severe group were higher than those in the moderate group(P＜0.05).URH,VASH-1 was positively correlated with BUN,Scr,whereas UACR(P＜0.05);ATG7 was negatively correlated with BUN,Scr,and UACR(P＜0.05).The eGFR of DN patients was calculated as 688.91-2.09×URH-1.66×VASH-1+78.17×ATG7,indicating a close relationship between URH,VASH-1,ATG7,and eGFR changes in DN patients.Conclusion As the severity of renal function impairment in DN patients increases,serum URH and VASH-1 levels rise,while ATG7 levels decrease.Renal function in DN patients is positively correlated with URH and VASH-1,while negatively correlated with ATG7.关键词
2型糖尿病/肾病/尿酸/HDLC/内源性血管生成抑制蛋白-1/自噬相关蛋白7Key words
type 2 diabetes/nephropathy/uric acid/HDLC/vasohibin-1/autophagy-related protein 7分类
临床医学引用本文复制引用
韦唯,汤晶..血清URH、VASH-1、ATG7水平与2型糖尿病肾病患者病情程度及肾功能指标的相关性[J].中南医学科学杂志,2025,53(2):365-368,4.基金项目
湖北省科技厅科研课题(2020CFB630) （2020CFB630）
