临床神经外科杂志2025，Vol.22Issue(2)：222-225,4.DOI:10.3969/j.issn.1672-7770.2025.02.018
铁死亡与胶质瘤放化疗敏感性相关研究进展
Research progress on ferroptosis and sensitivity of glioma to chemoradiotherapy
摘要
Abstract
Ferroptosis is a new type of cell death characterized by lipid peroxidation and reactive oxygen species(ROS)accumulation.A large number of studies show that ferroptosis plays an important role in the occurrence and development of various tumors.It is currently believed that targeting ferroptosis can inhibit tumor growth and increase the sensitivity of various tumors to radiotherapy and chemotherapy.Therefore,inducing ferroptosis expands tumor treatment strategies.Glioma is the most common brain tumor in adults.Surgical resection combined with postoperative adjuvant radiotherapy and chemotherapy is the standard treatment strategy.However,the therapeutic effect is poor.In recent years,research on ferroptosis has found that it regulates glioma radiotherapy sensitivity by inhibiting glutathione synthesis and promoting lipid peroxidation.Activating ferroptosis may become a new target for drugs,which may help improve the prognosis of glioma patients.This article reviews the latest research progress and potential mechanisms of ferroptosis in glioma,and systematically discusses the clinical application prospects of targeting ferroptosis to improve patient survival,aiming to provide a theoretical basis for exploring new strategies for glioma treatment.关键词
胶质瘤/铁死亡/放疗敏感性/化疗敏感性Key words
glioma/ferroptosis/radiotherapy/chemosensitivity分类
医药卫生引用本文复制引用
贺家凯,孙鹏飞..铁死亡与胶质瘤放化疗敏感性相关研究进展[J].临床神经外科杂志,2025,22(2):222-225,4.基金项目
甘肃省卫生健康行业科研计划项目(GSWSKY2023-04) （GSWSKY2023-04）
