中国海洋大学学报（自然科学版）2025，Vol.55Issue(5)：118-127,10.DOI:10.16441/j.cnki.hdxb.20240101
碲化铋前药纳米平台用于光热协同化疗抗肿瘤
A Bismuth Telluride-Based Prodrug Nano-Platform is Utilized for Photo-Thermal Synergistic Chemo-Therapy Against Tumors
摘要
Abstract
One of the important goals of biomedical research is to develop highly efficient and low-tox-icity anti-tumor drugs.In this study,bovine serum albumin(BSA)-modified bismuth telluride nanoshe-ets(Bi2Te3-BSA NSs)were prepared via a solvothermal method,significantly enhancing the stability and biocompatibility of tellurium.Bi2Te3-BSA NSs exhibit excellent photothermal conversion capabili-ty,effectively killing tumor cells.At the same time,the degradation product Te(Ⅳ)of Bi2Te3-BSA NSs can disrupt mitochondrial membrane potential and promote cell apoptosis.In vitro studies have shown that after photothermal synergistic chemotherapy treatment with Bi2Te3-BSA NSs,the survival rate of MCF-7 cells was only 2.3％,demonstrating promising anti-tumor potential.This study provides a new strategy for the use of inorganic nano-prodrug platforms for photothermal synergistic chemothera-py against tumors and holds promise for the field of cancer treatment.关键词
Bi2Te3前药平台/光热/化疗/线粒体功能障碍/抗肿瘤Key words
Bi2Te3 prodrug platform/photothermal/chemotherapy/mitochondrial dysfunction/anti-tumor分类
医药卫生引用本文复制引用
傅晨晨,仇萌..碲化铋前药纳米平台用于光热协同化疗抗肿瘤[J].中国海洋大学学报（自然科学版）,2025,55(5):118-127,10.基金项目
中央高校基础科研专项项目(202341006)资助Supported by the Fundamental Research Funds for the Central Universities(202341006) （202341006）
