皮革科学与工程2025，Vol.35Issue(2)：1-7,7.DOI:10.12472/j.issn.1004-7964.200400148
基于仿生矿化策略的多酚-胶原晶体材料构筑
Construction of Polyphenol-Collagen Crystals via Biomimetic Mineralization
摘要
Abstract
The assembly of collagen with natural organic molecules into crystalline structures offers promising avenues for the development of novel collagen-based biomaterials.However,the synthesis of such crystalline composite materials presents significant challenges due to the complexity of the underlying mechanisms,and systematic studies in this area remain scarce.In this study,we successfully constructed a crystalline material by employing a biomimetic mineralization strategy using the small-molecule polyphenol ellagic acid in conjunction with collagen.The mineralization process was governed by the concentration of collagen,commencing with the formation of hydrogen bonding between the phenolic hydroxyl groups of ellagic acid and the carboxyl groups of collagen,followed by self-assembly into its final morphology through hydrogen bonding and π-π interactions.The resulting material exhibited a cuboid-like morphology with length ranging from 20 to 30 micrometers.Characterization techniques,including laser confocal fluorescence microscopy,revealed a uniform distribution of collagen within the crystal.X-ray diffraction analysis confirmed that the material possesses a well-ordered lattice structure.Due to the stability of this crystal structure,the material maintains its structural integrity under various harsh conditions.This study provides novel methods and strategies for collagen self-assembly,offering valuable insights into collagen-based biomaterials.关键词
胶原/多酚/鞣花酸/自组装/晶体/仿生矿化Key words
collagen/polyphenol/ellagic acid/self-assembly/crystals/biomimetic mineralization分类
化学化工引用本文复制引用
谢秋萍,吴月,张豪杰,洪工画,何云翔,郭俊凌..基于仿生矿化策略的多酚-胶原晶体材料构筑[J].皮革科学与工程,2025,35(2):1-7,7.基金项目
国家重点研发计划(2022YFA0912800) （2022YFA0912800）
国家海外高层次人才计划(00308054A1045) （00308054A1045）
国家自然科学基金(22178233,22408241) （22178233,22408241）
四川省博士后特别资助(TB2022063) （TB2022063）
