南阳师范学院学报2025，Vol.24Issue(3)：63-71,9.
网络药理学探究升麻鳖甲汤治疗骨髓增生异常综合征的分子机制
Investigating the molecular mechanisms of Shengma Biejia Tang in treating Myelodysplastic Syndrome through network pharmacology
摘要
Abstract
The research aims to explore the molecular mechanism of Shengma Biejia Tang in the treatment of My-elodysplastic Syndrome using network pharmacology.The research methods are as follows:The components and composition targets of Shengma Biejia Tang were collected using TCMSP,HERB prediction databases.The dis-ease targets of Myelodysplastic Syndrome were screened by Gene Cards,DisGeNET,and TTD disease databases.Common targets of drug component targets and disease targets were screed by Venn diagram.PPI network was used to screen core targets.Common targets were used for GO and KEGG enrichment analysis.The research re-sults are as follows:125 chemical components,673 composition targets,824 disease targets,and 129 common targets were screened from Shengma Biejia Tang.833 GO entries and 160 KEGG signaling pathways were ob-tained through enrichment analysis of common targets.Based on the research,the following conclusions have been drawn:Shengma Biejia Tang may act on targets such as TP53,STAT3,and MYC,regulating the PI3K-Akt signaling pathway,JAK-STAT signaling pathway,and HIF-1 signaling pathway through Quercetin,Stigmasterol,and 9,12-Octadecadienoic acid in a multi-target,multi-pathway manner.关键词
网络药理学/升麻鳖甲汤/骨髓增生异常综合征/关键靶点/信号通路Key words
network pharmacology/Shengma Biejia Tang/Myelodysplastic Syndrome/key targets/signal pathway分类
医药卫生引用本文复制引用
孙振伟,邵志萱,陈家升,赵磊恒,宫宁宁,周易,柳文敏,郭珍珍..网络药理学探究升麻鳖甲汤治疗骨髓增生异常综合征的分子机制[J].南阳师范学院学报,2025,24(3):63-71,9.基金项目
国家自然科学基金青年项目(82104697) （82104697）
南阳师范学院博士专项(2023ZX006,2020ZX015) （2023ZX006,2020ZX015）
南阳师范学院STP项目(2023STP001) （2023STP001）
南阳师范学院国家自然基金培育项目(2023PY015) （2023PY015）
南阳师范南阳师范学院理工科校级青年项目(2025QN027) （2025QN027）
