摘要
Abstract
Objective:To explore the clinical efficacy of Qinggan Lishi Granule combined with Entecavir in the treatment of patients with hepatitis B cirrhosis with liver-gallbladder damp-heat.Methods:A total of 82 patients with liver cirrhosis due to damp-heat in liver-gallbladder admitted to Chifeng City Hospital from January 2021 to January2023 were selected as the study objects,and were divided into a control group and a study group by random number table method,with 41 cases in each group.The control group was treated with Entecavir,while the study group was treated with Entecavir and Qinggan Lishi Granule.Both groups were treated for 6 months The total effective rate of treatment,biochemical indexes,imaging characteristics,Hepatitis B virus deoxyribonucleic acid(HBV-DNA)conversion and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 97.56%,which was higher than 68.29%in the control group,with statistical significance(P<0.05).After 1 month of treatment,the alanine aminotransferase,aspartate aminotransferase,total bilirubin levels in the study group were lower than those in the control group,with statistical significance.(P<0.05).After 1 month of treatment,the maximum flow rate of portal vein and splenic vein in the study group were slower than those in the control group,the inner diameter of portal vein and spleen vein were smaller than those of control group,with statistical significance(P<0.05).The negative conversion rate of HBV-DNA in the study group was 97.56%,which was higher than 80.49%in the control group,the incidence of adverse reactions in the study group was 4.88%,which was lower than 24.39%in the control group,with statistical significance(P<0.05).Conclusion:The use of Qinggan Lishi Granule combined with Entecavir in the treatment of patients with liver-gallbladder damp-heat hepatitis B cirrhosis is conducive to improving the treatment effect,improving biochemical and imaging indicators,increasing the rate of HBV-DNA conversion to negative,and reducing the incidence of adverse reactions.关键词
肝胆湿热型/乙肝肝硬化/清肝利湿颗粒/恩替卡韦/临床疗效/不良反应Key words
Liver-gallbladder damp-heat type/Hepatitis B cirrhosis/Qinggan Lishi Granule/Entecavir/Clinical efficacy/Adverse effect分类
医药卫生
