中南医学科学杂志2025，Vol.53Issue(2)：189-194,6.DOI:10.15972/j.cnki.43-1509/r.2025.02.001
cGAS-STING通路调控巨噬细胞极化的研究进展
Research progress on cGAS-STING pathway in regulating macrophage polarization
摘要
Abstract
As crucial immune effector cells,macrophages differentiate into functionally distinct subtypes through polarization.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon gene(STING)pathway plays a pivotal role in innate immunity.Recent studies have revealed that this pathway regulates macrophage polarization by regulating cyto-kine secretion and metabolic reprogramming,thereby influencing the progression of infectious and inflammatory diseases including ath-erosclerosis.This review systematically elucidates the regulatory mechanisms of cGAS-STING pathway in macrophage polarization and its implications in disease pathogenesis,providing novel insights for developing targeted immunomodulatory therapies.关键词
cGAS-STING通路/巨噬细胞极化/免疫调控/治疗策略Key words
cGAS-STING pathway/macrophage polarization/immune regulation/therapeutic strategy分类
医药卫生引用本文复制引用
袁楚楚,余博,危当恒..cGAS-STING通路调控巨噬细胞极化的研究进展[J].中南医学科学杂志,2025,53(2):189-194,6.基金项目
国家自然科学基金项目(31870937) （31870937）
湖南省自然科学基金(2024JJ5339) （2024JJ5339）
