山东医药2025，Vol.65Issue(4)：54-58,5.DOI:10.3969/j.issn.1002-266X.2025.04.011
血清尿酸动态变化与健康体检人群新发高血压的相关性及其预测效能
Correlation between serum uric acid dynamic changes and incidence of new-onset hypertension in health examination populations and their predictive efficacy
摘要
Abstract
Objective To investigate the association between dynamic changes in serum uric acid(ΔsUA)and the incidence of new-onset hypertension in a health examination population,and to evaluate the predictive efficacy of ΔsUA and baseline serum uric acid(sUA)for new-onset hypertension.Methods Subjects from Health Management Center of the First Affiliated Hospital of Shandong First Medical University(Shandong Qianfushan Hospital)in 2019-2021 were se-lected for the study.ΔsUA was defined as the difference between the 2021 sUA value minus the 2019 sUA value.Stratifi-cation was based on sex and quartiles of ΔsUA.The correlation between ΔsUA and new-onset hypertension was analyzed using Logistic regression risk models with stepwise adjustment.We drew the restricted cubic spline plot and forest plot to further analyze the correlation between ΔsUA and new-onset hypertension.In addition,the predictive efficacy of sUA andΔsUA for the new-onset hypertension was compared using receiver operating characteristic(ROC)curves.Results We included 1,222 healthy individuals(male-to-female ratio:1,205:1,917)from health examinations of March 2019 and identified 621 new-onset hypertension cases in 2021.Logistic regression analysis showed that ΔsUA was significantly asso-ciated with new-onset hypertension in the total population,with an adjusted odds ratio(OR)of 1.008(95%CI:1.006-1.009;P<0.05).When we stratified the population by gender,women exhibited a stronger trend of increasing hyperten-sion risk compared to men as ΔsUA levels rose.Specifically,in the Q4 group(ΔsUA≥55 µmol/L),the OR(95%CI)was 3.207(2.192-4.692)for women versus 2.076(1.396-3.089)for men.Using quartile stratification with the Q2 group(-49.25 to<1.00 µmol/L)as the reference,we observed the lowest hypertension risk in the Q1 group(ΔsUA<-49.25 µmol/L;OR=0.537,95%CI:0.401-0.721).The risk progressively increased in the Q3(1.00-<55.00 µmol/L;OR=2.724,95%CI:2.013-3.686)and Q4 groups(≥55 µmol/L;OR=4.882,95%CI:3.577-6.664),with both P<0.05.For predictive performance,the optimal cut-off value for baseline sUA was 0.398 µmol/L,yielding a sensitivity of 0.690 and specificity of 0.707.The ΔsUA cut-off of 0.541 µmol/L showed improved predictive accuracy with sensitivi-ty of 0.768 and specificity of 0.773.Conclusions ΔsUA is associated with new-onset hypertension in the healthy check-up population and increased ΔsUA serves as an independent risk factor for new-onset hypertension in this population.The risk of new-onset hypertension is higher in women than in men,and ΔsUA demonstrates predictive value for new-onset hy-pertension in the healthy check-up population.关键词
血清尿酸动态变化/基线血清尿酸/新发高血压/性别差异Key words
serum uric acid changes/basal serum uric acid/new-onset hypertension/gender difference分类
临床医学引用本文复制引用
王东伟,刘芷含,苏彤,吴道兴,杨广,孟令东..血清尿酸动态变化与健康体检人群新发高血压的相关性及其预测效能[J].山东医药,2025,65(4):54-58,5.基金项目
2021年度青海省"昆仑英才·高端创新创业人才"计划 （）
青岛市科技惠民示范引导专项(22-3-7-smjk-8-nsh). （22-3-7-smjk-8-nsh）
