中南医学科学杂志2025，Vol.53Issue(2)：232-235,4.DOI:10.15972/j.cnki.43-1509/r.2025.02.009
低浓度阿托品对LIM豚鼠屈光度、眼轴及巩膜氧化应激的影响
Effects of low-concentration of atropine on refraction,axial length,and scleral oxidative stress in lens-induced myopia guinea pigs
摘要
Abstract
Aim To investigate the effects of low-concentration of atropine(ATR)on refraction,axial length,and scleral oxidative stress in lens-induced myopia(LIM)guinea pigs.Methods Thirty LIM guinea pigs were randomly divided into control group(right eye treated with 0.3％sodium hyaluronate once daily),ATR1 group(right eye treated with ATR once daily),and ATR2 group(right eye treated with ATR twice daily).Refraction,axial length,scleral histopathology,superoxide dismutase(SOD)activ-ity,and malondialdehyde(MDA)content were measured.Results After the experiment,the left eyes of all groups showed de-creased refraction and SOD activity,increased axial length,and elevated MDA levels(P＜0.05).The right eyes of ATR1 and ATR2 groups exhibited higher refraction and SOD activity,shorter axial length,and lower MDA levels compared to the left eyes(P＜0.05).The right eyes showed refraction and SOD activity,following an order of ATR2 group＞ATR1 group＞control group,while axial length and MDA levels followed an order of ATR2 group＜ATR1 group＜control group(P＜0.05).ATR delayed scleral pathological progression.Conclusion Low-concentration of atropine administered twice daily significantly delayed refraction and axial length progression,inhibited scleral pathology,and reduced oxidative stress in LIM guinea pigs.关键词
低浓度阿托品/LIM/眼轴长度/巩膜组织形态/氧化应激/豚鼠Key words
low-concentration atropine/LIM/axial length/scleral morphology/oxidative stress/guinea pig分类
医药卫生引用本文复制引用
杨婉晨,符俊达,朱海萍,贾娜,孙轶军..低浓度阿托品对LIM豚鼠屈光度、眼轴及巩膜氧化应激的影响[J].中南医学科学杂志,2025,53(2):232-235,4.基金项目
秦皇岛市科学技术研究与发展计划项目(202301A190) （202301A190）
