中南医学科学杂志2025，Vol.53Issue(2)：245-248,4.DOI:10.15972/j.cnki.43-1509/r.2025.02.012
单核细胞TLR4+896、+1196基因多态性与缺血性脑卒中患者并发泌尿系感染的关系
The Relationship between monocyte TLR4+896 and+1196 gene polymorphism and urinary tract infection in patients with ischemic stroke
摘要
Abstract
Aim To investigate the relationship between Toll-like receptor 4(TLR4)+896 and+1196 gene polymorphisms in monocytes and the occurrence of urinary tract infections in patients with cerebral ischemic stroke(CIS).Methods Fifty-seven CIS patients with UTIs(UTI group)and 50 CIS patients without UTIs(control group)were selected.Flow cytometry was used to de-tect TLR4 expression levels on monocyte surfaces,and PCR combined with sequencing was used to detect single nucleotide polymor-phisms(SNPs)at TLR4 loci+896A/G and+1196C/T.Logistic regression analysis was performed to identify influencing factors of UTIs.Results The levels of TLR4,as well as the proportions of patients with indwelling catheters and comorbid diabetes,were significantly higher in the urinary infection group compared to the control group(P＜0.05).Compared with the control group,the u-rinary infection group exhibited a lower frequency of the TLR4+896 AA genotype and allele A,while the frequencies of the TLR4+896 GG genotype,allele G,TLR4+1196 TT genotype,and allele T were significantly higher(P＜0.05).Logistic regression analysis re-vealed that indwelling catheters,comorbid diabetes,and TLR4+896G/A were influencing factors for urinary tract infections in CIS pa-tients(P＜0.05).Compared with patients without indwelling catheters,those with indwelling catheters had a lower frequency of the TLR4+896 allele A and a higher frequency of allele G(P＜0.05).Conclusion Catheterization and diabetes are risk factors for UTIs in CIS patients,and TLR4+896G/A is associated with the occurrence of UTIs in CIS patients.关键词
Toll样受体4/缺血性脑卒中/泌尿系感染/基因多态性Key words
Toll-like receptor 4/ischemic stroke/urinary tract infection/gene polymorphism分类
医药卫生引用本文复制引用
朱喜悦,刘佳,张洁..单核细胞TLR4+896、+1196基因多态性与缺血性脑卒中患者并发泌尿系感染的关系[J].中南医学科学杂志,2025,53(2):245-248,4.基金项目
上海市"科技创新行动计划"医学创新研究领域项目(20210203) （20210203）
