中南医学科学杂志2025，Vol.53Issue(2)：260-263,4.DOI:10.15972/j.cnki.43-1509/r.2025.02.016
circ-CCDC66联合CEA、CA19-9在结直肠癌诊断中的应用及其与临床病理特征的关系
Application of circ-CCDC66 combined with CEA and CA19-9 in the diagnosis of colorectal cancer and its relationship with clinicopathological characteristics
摘要
Abstract
Aim To investigate the application of circular RNA coiled-coil domain-containing protein 66(circ-CCDC66)combined with carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)in the diagnosis of colorectal cancer(CRC),as well as its relationship with clinicopathological characteristics.Methods A total of 50 CRC patients(CRC group),50 intestinal polyp patients(polyp group),and 50 healthy controls(control group),were selected.The levels of circ-CCDC66,CEA,and CA19-9 were compared among the groups,and the diagnostic efficacy of each indicator for CRC was analyzed.The CRC group was divided into low-expression and high-expression subgroups based on circ-CCDC66 levels,and the clinicopathological charac-teristics of the two subgroups were compared.Results The levels of circ-CCDC66,CEA,and CA19-9 in the CRC group were higher than those in the polyp group and the control group(P＜0.05).ROC curve analysis showed that circ-CCDC66,CEA,and CA19-9 had good diagnostic efficacy for CRC,and the combined diagnostic efficacy was higher than that of individual indicators(P＜0.05).The high-expression subgroup had a higher proportion of CRC patients with tumor size ≥5 cm,lymph node metastasis,clini-cal stage Ⅲ+Ⅳ,and neural invasion compared to the low-expression subgroup(P＜0.05).Conclusion The combination of circ-CCDC66,CEA,and CA19-9 has high diagnostic efficacy for CRC,and the level of circ-CCDC66 is closely related to the clinicopatho-logical characteristics of CRC.关键词
circ-CCDC66/CEA/CA19-9/结直肠癌/临床病理特征Key words
circ-CCDC66/CEA/CA19-9/colorectal cancer/clinicopathological characteristics分类
医药卫生引用本文复制引用
韩卓婷,林小聪,曾涛..circ-CCDC66联合CEA、CA19-9在结直肠癌诊断中的应用及其与临床病理特征的关系[J].中南医学科学杂志,2025,53(2):260-263,4.基金项目
广东省钟南山医学基金会资助项目(ZNSXS-20240012) （ZNSXS-20240012）
湛江市科技计划项目(2021A05102) （2021A05102）
