山东医药2025，Vol.65Issue(4)：88-92,5.DOI:10.3969/j.issn.1002-266X.2025.04.018
久坐行为与急性胰腺炎发病风险的关系:基于英国生物银行的队列研究
Association between sedentary behavior and risk of acute pancreatitis:a cohort study based on the UK Biobank
摘要
Abstract
Objective To investigate the association between sedentary behavior and the risk of acute pancreatitis(AP)and to provide references for AP prevention.Methods A cohort of 480,716 participants from the UK Biobank was included.Exposure variable(sedentary time)and covariates(age,sex,ethnicity,education level)were collected.Sedentary time was stratified by interquartile range into four groups:<3.0,3.0-<4.5,4.5-<6.0,and≥6.0 h/d.Base-line characteristics across groups were compared.Kaplan-Meier survival curves analyzed cumulative AP incidence.Re-stricted cubic spline models fitted Cox proportional hazards models to evaluate the nonlinear relationship between sedentary time and AP risk.Incremental Cox proportional hazards model was used to analyze the impact of sedentary behavior on the risk of acute pancreatitis.Results Among 480,716 participants,2,937 developed AP(incidence:0.61%).There were significant differences in the baseline information of gender,age,ethnicity,employment status,and education level of the study participants stratified by time of sedentary behaviour(all P<0.01).Kaplan-Meier curves demonstrated higher cumulative AP incidence with prolonged sedentary time(P<0.01).Restricted cubic spline analysis revealed a nonlinear relationship between sedentary time and AP risk(P=0.016 7).Incremental Cox regression model confirmed a significant dose-response association,with risk intensifying as sedentary time increased.Conclusion Prolonged sedentary time is associated with an elevated risk of AP,exhibiting a threshold effect.关键词
久坐行为/急性胰腺炎/发病风险/队列研究/英国生物银行Key words
sedentary behavior/acute pancreatitis/disease risk/cohort study/UK Biobank分类
临床医学引用本文复制引用
杨雨晴,董小武,路国涛,潘佳佳..久坐行为与急性胰腺炎发病风险的关系:基于英国生物银行的队列研究[J].山东医药,2025,65(4):88-92,5.基金项目
国家自然科学基金青年科学基金项目(82200720) （82200720）
江苏省卫健委科研课题项目(Y12023039) （Y12023039）
江苏省卫生健康委医学科研面上项目(M2024105) （M2024105）
扬州市政策引导类计划(国际科技合作)项目(YZ2022207) （国际科技合作）
扬州市卫生健康委科研项目(2023-2-03). （2023-2-03）
