四川师范大学学报（自然科学版）2025，Vol.48Issue(4)：440-456,17.DOI:10.3969/j.issn.1001-8395.2025.04.002
纳米酶参与的仿生级联催化在生物医学中的应用
Biomimetic Cascade Catalysis of Nanozyme for Biomedical Applications
摘要
Abstract
Enzymatic cascade reactions represent a common metabolic pathway in biological systems,whereby a substrate is con-verted into a final product through a series of enzymatic reactions.However,the disadvantages of biological enzymes,such as high cost,poor stability and susceptibility to inactivation,restrict their application in harsh environments.Nanozymes,as an alternative to conventional enzymes,not only exhibit similar catalytic activity but also have excellent stability,tunable catalytic properties,and high adaptability to pH value and temperature.These characteristics have promoted extensive research and application of nanozymes in the construction of biomimetic catalytic cascade systems.This paper presents a review of the recent research progress and advantages of cascade reaction systems involving different types of natural enzymes and artificial nanozymes.Subsequently,an exhaustive examination of nanozymes-enhanced biomimetic catalytic cascade systems for biomedical applications,including antimicrobial,antitumor and an-tioxidant applications,is provided.Finally,the article addresses the challenges of nanozymes-activated cascade reactions and offers in-sights into future directions,with the aim of providing a reference point for future research and applications.关键词
纳米酶/级联催化/抗菌/抗肿瘤/抗氧化Key words
nanozymes/cascade catalysis/antibacterial/antitumor/antioxidant分类
生物工程引用本文复制引用
李吉东,刘江山..纳米酶参与的仿生级联催化在生物医学中的应用[J].四川师范大学学报（自然科学版）,2025,48(4):440-456,17.基金项目
国家自然科学基金面上项目(32371398)和四川省国际合作计划项目(2023YFH0064) （32371398）
