摘要
Abstract
Objective To analyze the distribution characteristic of Clopidogrel-metabolizing enzyme CYP2C19 gene polymorphphisms in Han population of Wenzhou region.Methods A total of 431 Han population in Wenzhou who were tested for CYP2C19 gene between January 2 022 to July 2 023 were enrolled.The CYP2C19 gene polymorphisms were ana-lyzed,and were compared with the existing data of other areas in China.Results The frequencies of CYP2C19 *1,*2,*3 alleles were 60%,35.9%,and 4.1%,respectively.The frequencies of CYP2C19 *1/*1,*1/*2,*1/*3,*2/*2,*2/*3,*3/*3 genotypes were 35%(151/431),44.3%(191/431),5.8%(25/431),12.8%(55/431),1.9%(8/431),0.2%(1/431),respectively.The frequencies of extensive metabolizers,intermediate metabolizers and poor metabolizers were 35%(151/431),50.1%(216/431),and 14.9%(64/431),respectively.There were no significant differences in the distribution of CYP2C19 alleles,genotypes,or metabolizers between individuals aged≤60 years and>60 years in the Han Chinese population of Wenzhou region(all P>0.05).There were no significant differences in the distribution of CYP2C19 alleles,genotypes or metabolizers between male and females(all P>0.05).The distributions of CYP2C19 al-leles,genotypes and metabolizers in Wenzhou Han population were not significantly different from those in Taizhou,Hu-zhou,Hubei,Jinhua,Yunnan,Ningde,Suzhou,Shenyang,Chongqing,Kunming and Xinjiang Han populations(all P>0.05).However,the distributions were significantly different from those of Han population in Sichuan and Hangzhou(all P<0.05).There were statistically significant differences in the distribution of all CYP2C19 alleles between the Han Chi-nese populations in Wenzhou and Guangzhou regions.Conclusion The distribution of CYPC219 gene polymorphism in the Han population in Wenzhou region not related to age or gender,and is similar to that of Han population in most areas of China,but it is different from that of a few regions of China.关键词
氯吡格雷药物代谢酶/CYP2C19基因/基因多态性/汉族人群/温州地区Key words
Clopidogrel drug-metabolizing enzyme/CYP2C19 gene/gene polymorphism/Han population/Wen-zhou region分类
医药卫生
