山东医药2025，Vol.65Issue(4)：108-111,118,5.DOI:10.3969/j.issn.1002-266X.2025.04.022
血清IL-6、NT-proBNP水平对系统性硬化症无症状心肌纤维化的预测效能
Predictive efficacy of serum IL-6 and NT-proBNP levels for asymptomatic myocardial fibrosis in systemic sclerosis
摘要
Abstract
Objective To evaluate the predictive value of serum interleukin-6(IL-6)and N-terminal pro-brain natri-uretic peptide(NT-proBNP)in detecting asymptomatic myocardial fibrosis in patients with systemic sclerosis(SSc),there-by providing the references for early diagnosis and intervention for cardiac involvement in this population.Methods For-ty-two SSc patients without overt cardiovascular symptoms were enrolled.Myocardial fibrosis was assessed using cardiac magnetic resonance imaging(CMR).Serum IL-6 and NT-proBNP levels were measured via enzyme-linked immunosorbent assay(ELISA).Clinical and demographic data,including SSc subtype,Raynaud's phenomenon,digital ulcers,modified Rodnan skin score(mRSS),and anti-Scl-70/anti-centromere antibody status,were collected.Comparative analyses were performed between SSc patients with and without asymptomatic myocardial fibrosis.Multivariate Logistic regression was employed to identify independent predictors of myocardial fibrosis.Receiver operating characteristic(ROC)curve analysis was conducted to assess the diagnostic performance of IL-6,NT-proBNP,and their combination in predicting asymptomat-ic myocardial fibrosis.Results Among 42 SSc patients,18 cases had myocardial fibrosis and 24 cases did not;the inci-dence rate of asymptomatic myocardial fibrosis in SSc patients was 42.85%.Significant differences were observed in se-rum troponin I,NT-proBNP,IL-6,and mRSS between the fibrosis and non-fibrosis groups(all P<0.05).Multivariate analysis confirmed that IL-6,NT-proBNP,and mRSS were independent risk factors for asymptomatic myocardial fibrosis(all P<0.05).ROC analysis demonstrated that the area under the curve(AUC)of IL-6,NT-proBNP,and mRSS alone in predicting asymptomatic myocardial fibrosis was 0.841,0.670,and 0.836,respectively;the AUC of them combined was 0.940.Conclusions Serum IL-6 and NT-proBNP levels increase in SSc patients with asymptomatic myocardial fibrosis,and the elevated serum IL-6 and NT-proBNP levels are independent risk factors for asymptomatic myocardial fibrosis in SSc patients.The combination of these biomarkers with mRSS enhances predictive accuracy.关键词
系统性硬化症/心肌纤维化/白细胞介素6/N末端脑钠肽前体/磁共振成像Key words
systemic sclerosis/myocardial fibrosis/interleukin-6/N-terminal pro-brain natriuretic peptide precur-sor/magnetic resonance imaging分类
临床医学引用本文复制引用
王小冬,刘坚,丁振华..血清IL-6、NT-proBNP水平对系统性硬化症无症状心肌纤维化的预测效能[J].山东医药,2025,65(4):108-111,118,5.基金项目
浙江省丽水市科技计划项目(2021SJZC028). （2021SJZC028）
