上海针灸杂志2025，Vol.44Issue(4)：476-481,6.DOI:10.13460/j.issn.1005-0957.2025.04.0476
针刺联合隔姜灸治疗儿童变应性鼻炎合并鼻出血的疗效观察及对鼻黏膜菌群的影响
Effect of acupuncture plus ginger-insulated moxibustion in the treatment of allergic rhinitis with epistaxis in children and its influence on nasal mucosa flora
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with ginger-insulated moxibustion in the treatment of allergic rhinitis with epistaxis in children and its effect on nasal mucosa flora and levels of serum forkhead transcription factor p3(Foxp3),macrophage inflammatory protein 1α(MIP-1α),and tumor necrosis factor receptor 2(TNFR2).Method A total of 86 children with allergic rhinitis and epistaxis was allocated to a Western medication group(43 cases)and a traditional Chinese medicine(TCM)group(43 cases)according to the random number table method.The Western medication group treated with conventional Western medicine,and the TCM group was treated with additional acupuncture combined with ginger-insulated moxibustion.The clinical efficacy of the two groups was compared,and the nasal symptom score,total nasal symptom scores(TNSS),total non-nasal symptom scores(TNNSS),nasal resistance,nasal mucosa flora,prothrombin time,activated partial thromboplastin time,and serum Foxp3,MIP-1α and TNFR2 levels before and after treatment were observed in the two groups.Result The total effective rate was 97.7%in the TCM group and 79.1%in the Western medication group,and the difference was statistically significant(P＜0.05).After treatment,the nasal symptom score,TNSS,TNNSS,nasal resistance,and the abundance of Fusobacterium in nasal mucosa in the TCM group were lower than those in the Western medication group(P＜0.05);the abundance of Propionibacterium Acnes and actinobacteria in nasal mucosa in the TCM group were higher than that in the Western medication group(P＜0.05);the prothrombin time and activated partial thromboplastin time was shorter than that in the Western medication group(P＜0.05);the level of serum Foxp3 was higher than that in the Western medication group(P＜0.05);the levels of serum MIP-1α and TNFR2 were lower than those in the Western medication group(P＜0.05).Conclusion Acupuncture combined with ginger-partitioned moxibustion enhances treatment efficacy for pediatric allergic rhinitis with epistaxis by modulating nasal microbiota,improving coagulation function,and regulating inflammatory and immunological markers.关键词
针刺疗法/间接灸/针药并用/鼻炎,变应性/鼻出血/鼻黏膜菌群/凝血功能/儿童Key words
Acupuncture therapy/Indirect moxibustion/Acupuncture medication combined/Rhinitis,Allergic/Epistaxis/Nasal mucosa flora/Coagulation function/Child分类
医药卫生引用本文复制引用
王伊娜,张崧,胡志佳..针刺联合隔姜灸治疗儿童变应性鼻炎合并鼻出血的疗效观察及对鼻黏膜菌群的影响[J].上海针灸杂志,2025,44(4):476-481,6.基金项目
国家中医药管理局全国优秀人才研修项目(2020ZYLCY002-026) （2020ZYLCY002-026）
秦皇岛市科学技术研究与开发计划项目(202301A169) （202301A169）
