色谱2025，Vol.43Issue(5)：472-486,15.DOI:10.3724/SP.J.1123.2024.08012
脂质体与外泌体在药物递送和生物标志物筛选中的研究进展
Research advances of liposomes and exosomes in drug delivery and biomarker screening
摘要
Abstract
Vesicles,are categorized as artificial(i.e.,liposomes)or natural(i.e.,extracellular vesicles(EVs))and play significant roles in drug-delivery and biomarker-screening applica-tions.Liposomes,as a representative form of artificial vesicle,are spherical lipid structures composed of one or more artificially synthesized phospholipid bilayers.Liposomes are highly biocompatible and bioavailable,very stable,and easily synthesized;hence,they are among the most commonly used and frequently applied nanocarriers in targeted drug-delivery systems(DDS).EVs are natural small membrane-bound vesicles actively secreted by cells and contain a variety of components,including nucleic acids,proteins,and lipids.They also serve as impor-tant mediators of intercellular communication.As the smallest EV subtype,with diameters of only 30-100 nm,exosomes contain unique biomolecules that are considered to be the finger-prints of the parent cells.In the pathological state,the content of exosomes will change;conse-quently,exosomes are potential disease-diagnosis biomarkers.Recent clinical trials have shown that exosomes are ideal nanocarriers in targeted drug-delivery therapies for a variety of disea-ses.Compared with traditional artificial liposomal carriers,exosomes display unique advantages and provide the DDS field with new possibilities.Liposomes and exosomes are receiving increasing levels of attention in the drug-delivery and biomarker-screening fields.This article introduces techniques for the preparation of liposomes,and the enrichment and separation of exosomes,and delves into research progress on their use in drug-delivery and biomarker-screening applications.Finally,challenges facing the use of liposomes and exosomes in clinical applications are discussed.关键词
脂质体/外泌体/囊泡/富集和分离/药物递送/生物标志物筛选/综述Key words
liposomes/exosomes/vesicles/enrichment and separation/drug delivery/bio-marker screening/review分类
化学化工引用本文复制引用
苏雅婷,钱小红,秦伟捷..脂质体与外泌体在药物递送和生物标志物筛选中的研究进展[J].色谱,2025,43(5):472-486,15.基金项目
国家重点研发专项(No.2021YFA1302604).National Key R&D Program of China(No.2021YFA1302604). （No.2021YFA1302604）
