时珍国医国药2025，Vol.36Issue(7)：1267-1273,7.DOI:10.70976/j.1008-0805.SZGYGY-2025-0711
经典名方小续命汤基准样品关键质量属性量值传递研究
Study on the value transfer of critical quality attributes in the benchmark samples of Xiaoxum-ing Decoction(小续命汤)
摘要
Abstract
Objective To establish the characteristic chromatogram and a multi-component content determination method for the bench-mark samples of the classical prescription Xiaoxuming Decoction(小续命汤,XXMT).Methods HPLC was employed to assign charac-teristic peaks and determine the contents of 15 batches of benchmark samples,followed by quantitative transfer analysis.Results The characteristic chromatogram of the 15 batches of benchmark samples showed 18 common characteristic peaks,with 13 peaks identified as ephedrine hydrochloride,pseudoephedrine hydrochloride,and others.The similarity of the chromatograms ranged between 0.998 and 0.999.The contents of the benchmark samples were as follows:ephedrine hydrochloride(1.29-2.02 mg·g-1),pseudoephedrine hydrochloride(0.50-1.82 mg·g-1),paeoniflorin(7.34-10.93 mg·g-1),baicalin(19.33-26.81 mg·g-1),wogonoside(3.76-6.00 mg·g-1),ammonium glycyrrhizinate(1.19-3.27 mg·g-1),cimifugoside(1.38-2.12 mg·g-1),tetrandrine(0.17-0.48 mg·g-1),and baicalein(0.35-0.64 mg·g-1).Conclusion The established characteristic chromatogram and multi-component content determination method are simple,feasible,and demonstrate good reproducibility and stability,providing a founda-tion for quality evaluation of benchmark samples and preparations of the classical prescription XXMT.关键词
小续命汤/经典名方/基准样品/特征图谱Key words
Xiaoxuming Decoction(小续命汤)/Classical prescription/Benchmark samples/Characteristic chromatogram分类
医药卫生引用本文复制引用
刘臻茵,王雪颖,王雪仪,王俊帅,刘永利..经典名方小续命汤基准样品关键质量属性量值传递研究[J].时珍国医国药,2025,36(7):1267-1273,7.基金项目
河北省自然科学基金资助项目(H2022329003) （H2022329003）
