实用中医内科杂志2025，Vol.39Issue(4)：26-29,后插5-后插8,8.DOI:10.13729/j.issn.1671-7813.Z20241588
补肺益肾法治疗慢性阻塞性肺疾病稳定期有效性的Meta分析
A Meta-analysis of Tonifying Lung and Benefiting Kidney Method for Treating Stable-stage Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To systematically evaluate the efficacy of tonifying lung and benefiting kidney method in the treatment of chronic obstructive pulmonary disease(COPD)in stable stage.Methods A meta-analysis of 18 RCTs was performed using Rev-Man 5.3 software provided by the Cochrane Collaboration.Results Compared with the control group,the combined treatment with tonifying lung and benefiting kidney method could improve the lung function of patients with stable COPD:FEV1%[MD=5.96,95%CI(3.64,8.29),P＜0.000 01],FEV1/FVC[MD=5.53,95%CI(4.75,6.31),P＜0.000 01],IgA in 8-week group[MD=0.37,95%CI(0.27,0.48),P＜0.000 01],IgA in 12-week group[MD=0.35,95%CI(-0.01,0.72),P=0.05],IgG[MD=0.47,95%CI(0.39,0.55),P＜0.000 01];reduced IL-6[MD=-6.67,95%CI(-9.64,-3.71),P＜0.000 1],TGF-β1[MD=-18.37,95%CI(-28.64,-8.11),P=0.000 5],TNF-α[MD=-4.65,95%CI(-8.04,-1.26),P=0.007];improved CD+4[MD=3.76,95%CI(1.80,5.72),P=0.000 2],CD+8[MD=-3.93,95%CI(-4.43,-3.42),P＜0.000 01].There was no significant difference in IgMin the 8-week and 12-week groups[MD=0.25,95%CI(-0.04,0.54),P=0.09;MD=0.35,95%CI(-0.01,0.72),P=0.05],indicating that the improvement effect of tonifying lung and benefiting kidney method on IgMin the early stage was not obvious,and the initial effect of long-term treatment could be seen.Conclusion The treatment combined with tonifying lung and benefiting kidney method in the treatment of stable COPD patients is basically positive in terms of efficacy.However,due to the quality limitations of the included studies in this study,more strict,higher quality,larger sample size and multi-center clinical studies need to be designed in the future to demonstrate the results of this study.关键词
补肺益肾法/慢性阻塞性肺疾病稳定期/肺肾气虚证/Meta 分析Key words
tonifying lung and benefiting kidney method/stable chronic obstructive pulmonary disease/Qi deficiency of lung and kidney syndrome/Meta-analysis分类
医药卫生引用本文复制引用
张楚西,袁星与,杨朝晖,张春晓,朱振刚..补肺益肾法治疗慢性阻塞性肺疾病稳定期有效性的Meta分析[J].实用中医内科杂志,2025,39(4):26-29,后插5-后插8,8.基金项目
国家自然科学基金项目(81673900) （81673900）
