实用中医内科杂志2025，Vol.39Issue(4)：30-33,4.DOI:10.13729/j.issn.1671-7813.Z20241717
基于细胞焦亡探讨慢性萎缩性胃炎脾胃湿热证的生物学机制
Discussion on Biological Mechanism of Chronic Atrophic Gastritis with Dampness-heat of Spleen and Stomach Syndrome Based on Pyroptosis
摘要
Abstract
Chronic atrophic gastritis(CAG)is a chronic inflammatory disease,which plays a key role in the transformation of gastric mucosa from inflammation to cancer.Studies have shown that pyroptosis can induce gastric mucosal inflammation and par-ticipate in the progression of CAG.Dampness-heat of spleen and stomach syndrome in traditional Chinese medicine(TCM)is closely associated with the inflammatory level of gastric mucosa,which is a common TCMsyndrome of CAG in the clinic.Damp-ness and heat accumulate in spleen and stomach,damaging gastric collaterals,easily generating blood stasis and toxin over time,and inducing cancer.The pathogenesis of dampness-heat of spleen and stomach syndrome has commonalities with pyroptosis promoting inflammatory reaction and facilitating tumor development.Therefore,this paper deeply explored the relationship be-tween pyroptosis and dampness-heat of spleen and stomach syndrome,and investigated the molecular mechanism of CAG from the perspective of modern biology,in order to provide the relevant theoretical basis for TCMusing the method of clearing damp-ness and heat in treating CAG.关键词
慢性萎缩性胃炎/脾胃湿热证/细胞焦亡/生物学机制Key words
chronic atrophic gastritis/dampness-heat of spleen and stomach syndrome/pyroptosis/biological mechanism分类
医药卫生引用本文复制引用
王秋月,郑泽宇,黄铭涵,王文荣..基于细胞焦亡探讨慢性萎缩性胃炎脾胃湿热证的生物学机制[J].实用中医内科杂志,2025,39(4):30-33,4.基金项目
国家自然科学基金项目(82174365) （82174365）
福建省自然科学基金项目(2023J01821) （2023J01821）
