天津中医药2025，Vol.42Issue(4)：486-495,10.DOI:10.11656/j.issn.1672-1519.2025.04.13
白桦脂醇纳米乳处方筛选及制备工艺优化研究
Formulation screening and preparation process optimization of betulin nanoemulsion
摘要
Abstract
[Objective]To determine the process prescription for the preparation of Betulinol nano-emulsion.[Methods]Pseudo-ternary phase diagram method was used to screen the nano-emulsion prescription.The preparation process parameters were optimized using one-factor screening and effect surface method(Box-Behnken).[Results]The optimal prescription of betulinol nano-emulsion was:m(isopropyl myristate)∶m(tween 80)∶m(glycerol)∶m(distilled water)=15.38％∶20.51％∶41.03％∶23.08％.The optimum prescription process was:stirring temperature 53℃,stirring speed 1 050 r/min,stirring time 6.2 min.[Conclusion]The determined prescription process was stable and simple,reproducible,and produced nanoemulsions with high drug loading capacity.关键词
白桦脂醇/纳米乳/处方筛选/制备工艺Key words
betulin/nanoemulsion/formulation screening/preparation process分类
医药卫生引用本文复制引用
王德旺,蒙天琛,李鑫..白桦脂醇纳米乳处方筛选及制备工艺优化研究[J].天津中医药,2025,42(4):486-495,10.基金项目
黑龙江省重点研发计划指导类项目(GZ20210092). （GZ20210092）
