天津中医药2025，Vol.42Issue(4)：519-525,7.DOI:10.11656/j.issn.1672-1519.2025.04.17
中医药调控HIF-1α信号通路治疗心肌缺血再灌注损伤的研究进展
Research progress of HIF-1α signaling pathway regulated by traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury
摘要
Abstract
Acute myocardial infarction can minimize myocardial ischemic damage and limit the infarct size by thrombolysis,drugs that dilate blood vessels,and percutaneous coronary intervention,but restoration of blood perfusion of ischemic myocardial tissue will lead to myocardial ischemia-reperfusion injury(MIRI).In recent years,it has found that traditional Chinese medicine(TCM)has the unique advantages of multi-component,multi-pathway and multi-target in the treatment of MIRI.Hypoxia-inducible factor 1 alpha(HIF-1α)plays an important role in promoting cell survival and recovery and reducing the degree of myocardial damage by regulating oxidative stress,inflammatory response,angiogenesis,apoptosis and autophagy during MIRI.Therefore,this paper summarized the relationship between HIF-1α signaling pathway and the pathogenesis of MIRI,as well as the current research progress of TCM in regulating HIF-1αsignaling pathway to treat MIRI,in order to provide new ideas for the prevention and treatment of MIRI with TCM.关键词
HIF-1α信号通路/中医药/心肌缺血再灌注损伤/研究进展Key words
HIF-1α signaling pathway/traditional Chinese medicine/myocardial ischemia reperfusion injury/research progress分类
医药卫生引用本文复制引用
刘祎曼,贾慧雨,冯文帅,郭流漓,江丰,任明..中医药调控HIF-1α信号通路治疗心肌缺血再灌注损伤的研究进展[J].天津中医药,2025,42(4):519-525,7.基金项目
国家重点研发计划项目(2018YFC1707403). （2018YFC1707403）
