世界中医药2025，Vol.20Issue(2)：259-265,7.DOI:10.3969/j.issn.1673-7202.2025.02.011
基于动物模型的系统评价大柴胡汤对胆汁淤积的效果及作用机制
Efficacy and Mechanisms of Dachaihu Decoction against Cholestasis:A Systematic Review Based on Animal Models
摘要
Abstract
Objective:To comprehensively evaluate the efficacy and mechanisms of Dachaihu Decoction(DCHD)in different types of cholestasis animal models.Methods:A systematic search was conducted in PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),and Chinese Sci-tech Journal Database(CCD)from their inception to April 30,2023,to identify published animal studies on DCHD intervention in cholestasis.Two researchers inde-pendently screened reports,extracted relevant data,and assessed the risk of bias using the Systematic Review Center for Laboratory Animal Experimentation(SYRLE)tool and the quality of evidence using the GRADE-CERQual approach.Results:A total of 15 an-imal studies were included.Except for one study reporting that DCHD failed to alleviate bile duct ligation(BDL)-induced cholesta-sis,all other studies demonstrated the effectiveness of DCHD in various cholestasis models.The evidence supporting DCHD's effica-cy in extrahepatic cholestasis models was stronger than in intrahepatic models.In the analysis of DCHD's mechanisms,the quality of evidence for"inflammation"was rated as high,while"bile acid homeostasis"and"apoptosis"were rated as moderate.Mean-while,"oxidative stress""intestinal mucosal barrier",and"endoplasmic reticulum stress"received low-quality ratings.Conclu-sion:DCHD has a hepatoprotective effect and alleviates cholestasis in different animal models of cholestasis,with stronger evidence supporting its effects in extrahepatic models.Mechanistically,its anti-inflammatory effect has the highest quality rating,whereas its role in regulating bile acid homeostasis,apoptosis,oxidative stress,intestinal mucosal injury,and endoplasmic reticulum stress has relatively lower evidence quality.关键词
胆汁淤积/大柴胡汤/动物模型/机制研究/系统综述/质量评价/基础研究/定性研究Key words
Cholestasis/Dachaihu Decoction/Animal model/Mechanism research/Systematic review/Quality evaluation/Basic research/Qualitative research分类
中医学引用本文复制引用
姜德龙,张展,王庆谚,许斌..基于动物模型的系统评价大柴胡汤对胆汁淤积的效果及作用机制[J].世界中医药,2025,20(2):259-265,7.基金项目
国家自然科学基金青年科学基金项目(82004229) （82004229）
全国中医药高等教育"十四五"规划2021年度教育科研课题(ZD-20-09) （ZD-20-09）
沈阳市中医药专家学术经验继承项目(A10402) （A10402）
