上海交通大学学报（医学版）2025，Vol.45Issue(3)：335-341,7.DOI:10.3969/j.issn.1674-8115.2025.03.010
共病强迫型人格障碍对强迫症患者行为抑制/激活系统的影响
Effects of comorbid obsessive-compulsive personality disorder on the behavioral inhibition/activation systems in patients with obsessive-compulsive disorder
摘要
Abstract
Object·To explore the effects of comorbid obsessive-compulsive personality disorder(OCPD)on the behavioral inhibition system(BIS)/behavioral activation system(BAS)in patients with obsessive-compulsive disorder(OCD).Methods·A total of 247 patients with unmedicated OCD diagnosed in the Mental Health Center,Shanghai Jiao Tong University School of Medicine from 2014 to 2018 were included and divided into an OCD group(n=202),and an OCD+OCPD group(n=45),and 107 healthy controls were recruited as a comparison group.Yale-Brown Obsessive-Compulsion Scale(YBOCS),BIS/BAS Scale,Hamilton Depression Scale(HAMD),and Hamilton Anxiety Scale(HAMA)were used to assess psychopathological features.Gender differences among the three groups were analyzed using the x2 test.One-way analysis of variance(ANOVA)was used to compare differences in demographic characteristics,psychopathological features,and BIS/BAS scores,followed by the least significant difference(LSD)test for pairwise comparisons.Regression analysis was conducted to explore the relationships between psychopathological features and BIS/BAS scores.Results·There were no significant differences in gender,age,and years of education among the three groups.The scores of YBOCS(t=2.925,P=0.004),HAMD(t=2.130,P=0.034)and HAMA(t=2.568,P=0.011)in the OCD+OCPD group were significantly higher than those in the OCD group.There were statistically significant differences in BIS and BAS scores among the three groups(BIS:F=39.573,P＜0.001;BAS:F=3.915,P=0.021).The results showed that for BIS,there were statistically significant differences in pairwise comparisons among the three groups(OCD+OCPD vs OCD:P=0.002;OCD+OCPD vs HC:P＜0.001;OCD vs HC:P＜0.001),and the scores were OCD+OCPD＜OCD＜HC from low to high.For BAS,the OCD group scored significantly higher than the OCD+OCPD and HC groups(OCD+OCPD vs OCD:P=0.018;OCD vs HC:P=0.043),but there was no significant difference between the OCD+OCPD and HC groups.Regression models of BIS and BAS were constructed for OCD patients with OCPD,and the results showed that the overall prediction effect of the model was significant for BIS total scores(F=2.599,P=0.013).Only the severity of OCPD symptoms can significantly predict BIS scores(t=-2.282,P=0.023).For BAS total scores,the overall prediction effect of the model was not significant(F=1.438,P=0.191).Conclusion·Comorbid OCPD may be an adverse factor for abnormal BIS and a protective factor for abnormal BAS in patients with OCD.关键词
强迫症/强迫型人格障碍/行为抑制系统/行为激活系统Key words
obsessive-compulsive disorder/obsessive-compulsive personality disorder/behavioral inhibition system/behavioral activation system分类
医药卫生引用本文复制引用
周金静,张晨,杨桂萍,沈辉,张宗凤,高睿,陈永军,曹璇,范青..共病强迫型人格障碍对强迫症患者行为抑制/激活系统的影响[J].上海交通大学学报（医学版）,2025,45(3):335-341,7.基金项目
中国康复医学会科技发展项目 （）
上海市卫生健康委员会项目(202140054) （202140054）
上海市卫生健康委员会卫生健康学科带头人项目(2022XD025) （2022XD025）
上海交通大学医学院源申康复研究院项目(yskf1-23-1107-1) （yskf1-23-1107-1）
上海交通大学"交大之星"计划医工交叉研究基金(YG2021ZD28). Key Project of Science and Technology Development of Chinese Rehabilitation Medical Association （YG2021ZD28）
Project of Shanghai Municipal Health Commission(202140054) （202140054）
Health Discipline Leader Program of Shanghai Municipal Health Commission(2022XD025) （2022XD025）
Project of Yuanshen Rehabilitation Institute of Shanghai Jiao Tong University School of Medicine(yskf1-23-1107-1) （yskf1-23-1107-1）
Key Project of the"Star of Jiao Tong University"Medical and Industrial Cross Research Foundation of Shanghai Jiao Tong University(YG2021ZD28). （YG2021ZD28）
