天津科技大学学报2025，Vol.40Issue(2)：22-28,36,8.DOI:10.13364/j.issn.1672-6510.20240001
柴胡皂苷D改善抗癌药物环磷酰胺诱导的免疫功能低下
Saikosaponin D Ameliorating Immunosuppression Induced by Cyclophosphamide
摘要
Abstract
In order to explore the effect of saikosaponin D(SSD)on immunocompromised mice,the immunosuppressed mice induced by cyclophosphamide(CTX)were used to observe the effects of different doses of SSD on thymus and spleen indexes,blood cell counts,lymphocyte proliferation and macrophage function,serum IgG and IgM concentration,the ratio of CD4+and CD8+T cells and spleen cell apoptosis rate,structure of spleen and expression of JAK2/STAT3 signaling path-way.The results showed that except for the number of erythrocyte and thrombocyte,all indexes in CTX group were de-creased significantly(P＜0.05),spleen structure was destroyed and apoptosis was promoted.SSD could significantly im-prove the spleen structure,increase the proportion of CD4+T cells and reduce the apoptosis.The thymus index,leukocyte count and p-STAT3 expression were increased significantly in the low-dose SSD group(P＜0.05),while the body weight,leukocyte count,IgG level,T cell and B cell proliferation indexes,the ratio of CD8+T cells and JAK2/STAT3 signaling ex-pression were increased significantly in the high-dose SSD group(P＜0.05).Therefore,SSD could effectively enhance the immune function of CTX-induced immunocompromised mice,and the mechanism might be associated with the activation of JAK2/STAT3 pathway.关键词
柴胡皂苷D/环磷酰胺/免疫低下/JAK2/STAT3Key words
saikosaponin D/cyclophosphamide/immunocompromise/JAK2/STAT3分类
基础医学引用本文复制引用
陈云曦,刘夫锋..柴胡皂苷D改善抗癌药物环磷酰胺诱导的免疫功能低下[J].天津科技大学学报,2025,40(2):22-28,36,8.基金项目
天津市自然科学基金项目(18JCZDJC33000) （18JCZDJC33000）
