武警医学2025，Vol.36Issue(4)：310-313,4.
肺泡灌洗术后局部灌注布地奈德联合乙酰半胱氨酸对儿童重症肺炎的疗效
Effect of local infusion of budesonide combined with acetylcysteine in treatment of severe pneumonia in children after bronchoalveolar lavage
刘瑞华 1田晨 1燕燕 1张晶晶1
作者信息
- 1. 300162 天津,武警特色医学中心儿科
- 折叠
摘要
Abstract
Objective To investigate the effect of local perfusion of budesonide combined with acetylcysteine in the treatment of severe pneumonia in children after electronic bronchoscopic alveolar lavage(BAL).Methods A total of 74 children with severe pneumonia admitted to the Pediatric Department of Characteristics Medical Center of Chinese People's Armed Police Force from Sep-tember 2023 to August 2024 were selected and divided into an observation group(n=37)and a control group(n=37).On the basis of conventional treatment,the control group was treated with 0.9%NaCl alveolar lavage using electronic bronchoscopy,while the ob-servation group was treated with local infusion of budesonide combined with acetylcysteine in addition to the control group.The clinical efficacy,cough disappearance time,body temperature recovery time,inflammatory indicators,hospitalization time,and incidence of adverse reactions were observed respectively in the two groups.Results The clinical efficacy,inflammatory indicators,and hospitali-zation stay of the observation group were significantly better than those of the control group,with statistically significant difference(P<0.05).There was no statistically significant difference in the recovery time of body temperature,disappearance time of cough,and in-cidence of adverse reactions between the two groups.Conclusions Local infusion of budesonide combined with acetylcysteine after alveolar lavage is characterized by significant clinical effect in the treatment of children with severe pneumonia,which can accelerate the absorption of pulmonary inflammatory lesions,shorten the length of hospital stay and reduce inflammatory indicators.关键词
电子支气管镜/肺泡灌洗/重症肺炎/布地奈德/乙酰半胱氨酸Key words
electronic bronchoscope/alveolar lavage/severe neumonia/budesonide/acetylcysteine分类
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刘瑞华,田晨,燕燕,张晶晶..肺泡灌洗术后局部灌注布地奈德联合乙酰半胱氨酸对儿童重症肺炎的疗效[J].武警医学,2025,36(4):310-313,4.
