上海针灸杂志2025，Vol.44Issue(4)：402-406,5.DOI:10.13460/j.issn.1005-0957.2025.04.0402
时空针灸治疗失眠的疗效观察及对血清褪黑素和5-羟色胺水平的影响
Observation on the efficacy of space-time acupuncture for insomnia and its effect on serum melatonin and 5-hydroxytryptamine levels
摘要
Abstract
Objective To observe the clinical efficacy of space-time acupuncture for insomnia of heart-kidney disharmony type and its effect on serum melatonin(MT)and 5-hydroxytryptamine(5-HT)levels in the patients.Method Eighty patients with insomnia of heart-kidney disharmony type were randomized to a treatment group and a control group,with 40 cases in each group.The treatment group received space-time acupuncture with the eightfold method of the sacred tortoise and the control group,conventional acupuncture.The Pittsburgh sleep quality index(PSQI)and serum MT and 5-HT levels were observed in the two groups before and after treatment.The clinical therapeutic effects and the occurrences of adverse reactions were compared between the two groups.Result After treatment,the PSQI total score and various item scores decreased in the two groups(P＜0.05)and the PSQI total score,and the sleep latency,sleep duration,habitual sleep efficiency and sleep disturbances scores were lower in the treatment group than in the control group(P＜0.05).After treatment,serum MT and 5-HT levels increased in the treatment group compared with before(P＜0.05)and they were higher in the treatment group than in the control group(P＜0.05).The pre-/post treatment difference values of serum MT and 5-HT levels were higher in the treatment group than in the control group(P＜0.05).The total efficacy rate was 92.5%in the treatment group,which was significantly higher than 77.5%in the control group with a statistically significant difference(P＜0.05).Conclusion Space-time acupuncture is clinically more effective than conventional acupuncture in treating insomnia.It can improve sleep quality,which may be related to regulate serum MT and 5-HT levels.关键词
针刺疗法/时空针灸/灵龟八法/睡眠障碍/褪黑素/5-羟色胺Key words
Acupuncture therapy/Space-time acupuncture/Eightfold method of the sacred tortoise/Dyssomnia/Melatonin/5-hydroxytryptamine分类
医药卫生引用本文复制引用
刘亮先,王祖红,方永江,郭春艳,王英浩,盘雪娇,普菊华,朱勉生..时空针灸治疗失眠的疗效观察及对血清褪黑素和5-羟色胺水平的影响[J].上海针灸杂志,2025,44(4):402-406,5.基金项目
昆明市卫生健康委员会千工程卫生科研课题项目(2021-09-01-001) （2021-09-01-001）
云南省科技厅云南中医药大学应用基础研究联合专项面上项目(202101AZ070001-089) （202101AZ070001-089）
