世界中医药2025，Vol.20Issue(2)：327-335,9.DOI:10.3969/j.issn.1673-7202.2025.02.022
中药单体调控腺苷酸活化蛋白激酶信号通路防治脓毒症的研究进展
Chinese Medicine Monomers Regulate AMP-activated Protein Kinase Pathway in the Prevention and Treatment of Sepsis:A Review
摘要
Abstract
Sepsis is a systemic inflammatory response syndrome caused by infection.The AMP-activated protein kinase(AMPK)signaling pathway plays a role in the development of sepsis by regulating inflammation,improving mitochondrial function,modula-ting autophagy,inhibiting cell apoptosis,and regulating metabolism.Traditional Chinese medicine(TCM)has unique advantages in treating sepsis,one of which is its ability to regulate the AMPK signaling pathway through multiple pathways,effects,and targets.Chinese medicine monomers that prevent and treat sepsis via the AMPK signaling pathway include flavonoids(kaempferol,querce-tin,luteolin,isoquercitrin,puerarin,naringenin,and maackiain),phenols(curcumin,proanthocyanidins,rhodioloside,malvidin,and dehydroxylcurcumin),polysaccharides(astragalus polysaccharide),terpenoids(betulinic acid,nerolidol,artemisinin,and artesu-nate),lactones(atractylenolide Ⅲ),alkaloids(lycorine),glycosides(ginsenoside Rg3 and gardenoside),and lignans(sesamin and matairesinol).These monomers can activate or inhibit the AMPK signaling pathway,thereby affecting inflammation,cell apoptosis,and oxidative stress to prevent and treat sepsis.关键词
中药单体/AMP活化的蛋白激酶信号通路/脓毒症/黄酮类化合物/酚类化合物/多糖类化合物/药理活性/器官保护Key words
Chinese medicine monomers/AMP-activated protein kinase signaling pathway/Sepsis/Flavonoids/Phenolic com-pounds/Polysaccharide compounds/Pharmacological activity/Organ protection分类
中医学引用本文复制引用
刘柱,王佳巍,彭金婵,徐明瑶,黎丽群,谢胜..中药单体调控腺苷酸活化蛋白激酶信号通路防治脓毒症的研究进展[J].世界中医药,2025,20(2):327-335,9.基金项目
国家自然科学基金项目(82260900) （82260900）
国家中医药管理局高水平重点学科建设项目(zyyzdxk-2023167) （zyyzdxk-2023167）
广西科技计划项目(广西重点研发计划)(桂科AB23026098) （广西重点研发计划）
广西中医药多学科交叉创新团队项目(GZKJ2307) （GZKJ2307）
广西岐黄学者培养项目(2022015003-01) （2022015003-01）
