上海针灸杂志2025，Vol.44Issue(4)：418-423,6.DOI:10.13460/j.issn.1005-0957.2025.04.0418
针药并用治疗卒中后抑郁的疗效观察及对血清CX3CL1和CX3CR1水平的影响
Observation on the efficacy of combined acupuncture and medicine for post-stroke depression and its effect on serum CX3CL1 and CX3CR1 levels
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture plus fluoxetine capsules for post-stroke depression and its effect on serum CX3C chemokine ligand 1(CX3CL1)and CX3C chemokine receptor 1(CX3CR1)levels.Method One hundred and thirty patients with post-stroke depression were randomized to observation and control groups,with 65 cases in each group.The control group received oral administration of fluoxetine capsules and the observation group,acupuncture at points Baihui(GV20)and Yintang(GV29)in addition.The clinical therapeutic effects were compared between the two groups.The TCM symptom score,the Hamilton depression scale-17(HAMD-17)score and the National Institutes of Health stroke scale(NIHSS)score were recorded and serum CX3CL1,CX3CR1,5-hydroxytryptamine(5-HT)and glial cell derived neurotrophic factor(GDNF)levels were measured in the two groups before and after treatment.Result The total efficacy rate was 95.4%in the observation group,which was higher than 78.5%in the control group(P＜0.05).After treatment,the HAMD-17 and NIHSS scores decreased in the two groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).After treatment,serum CX3CL1 and CX3CR1 levels decreased in the two groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).After treatment,serum 5-HT and GDNF levels increased in the two groups(P＜0.05)and were higher in the observation group than in the control group(P＜0.05).Conclusion Combined use of acupuncture and medicine can relieve depression symptoms,improve nervous function,reduce serum CX3CL1 and CX3CR1 levels and increase serum 5-HT and GDNF levels in treating patients with post-stroke depression.Its therapeutic effect is better than that of medication alone.关键词
针刺疗法/针药并用/穴,百会(GV20)/穴,印堂(GV29)/中风/并发症/抑郁/CX3C趋化因子Key words
Acupuncture therapy/Acupuncture medication combined/Point,Baihui(GV20)/Point,Yintang(GV29)/Stroke/Complication/Depression/CX3C chemokine分类
医药卫生引用本文复制引用
刘海燕,李伟,宗兴燕..针药并用治疗卒中后抑郁的疗效观察及对血清CX3CL1和CX3CR1水平的影响[J].上海针灸杂志,2025,44(4):418-423,6.基金项目
国家自然科学基金项目(81904193) （81904193）
