低碳化学与化工2025，Vol.50Issue(4)：1-18,18.DOI:10.12434/j.issn.2097-2547.20240312
烷烃/烷基芳烃与一氧化碳的自由基羰基化研究进展
Research progress on radical carbonylation of alkanes or alkylarenes with carbon monoxide
摘要
Abstract
Carbonyl functional groups are widely present in the structures of natural products,pharmaceuticals,agrochemicals,and polymer materials.The development of innovative,efficient and green carbonylation methods is one of the hottest research topics in the field of synthetic chemistry.As important energies and chemical raw materials,alkanes and alkylarenes are widely prevalent in petroleum and natural gas.The highly selective preparation of high value-added carbonyl derivatives through direct carbonylation of C—H bonds,starting from simple alkanes(e.g.,cyclopentane,cyclohexane)or alkylarenes(e.g.,toluene,ethylbenzene),represents a challenging and promising research area.Among the diverse carbonyl donors,carbon monoxide(CO)is the most extensively utilized carbonylation reagent owing to its 100％atomic efficiency and cost-effectiveness.Based on the significant achievements in the field of radical carbonylation of alkanes or alkylarenes with carbon monoxide over the past fifteen years,the progress on the synthesis of high value-added carbonyl derivatives such as acids,esters,amides(including acyl hydrazides,amides,α-ketoamides,β-lactams and imides)and ketones(including chiral amino ketones)by utilizing peroxide-type compounds or photocatalysts as the initiators,and H2O,H2O2,alcohols,arylsulfinates,azodicarboxylates,amines,imines,amides or olefins as the reaction partners was summarized.Then,the product types of carbonylation reactions were classified and explained,and the substrate scopes and typical reaction mechanisms were discussed.Finally,the challenges and opportunities in the field of radical carbonylation of alkanes and alkylarenes were analyzed and prospected.关键词
烷烃/烷基芳烃/一氧化碳/自由基羰基化/高附加值羰基衍生物Key words
alkanes/alkylarenes/carbon monoxide/radical carbonylation/high value-added carbonyl derivatives分类
化学化工引用本文复制引用
孙巧,殷爱华,徐元,随山红,董岩,王昌盛,张东顺,郭凯..烷烃/烷基芳烃与一氧化碳的自由基羰基化研究进展[J].低碳化学与化工,2025,50(4):1-18,18.基金项目
江苏省青年基金(BK20220326) （BK20220326）
江苏省特聘教授项目(54908022) （54908022）
南京工业大学科研启动金(39808137,39829124) （39808137,39829124）
中国石化委托技术开发项目(202410038,202410043) （202410038,202410043）
南京工业大学食品与轻工学院学科基金(30929000). （30929000）
