畜牧与兽医2025，Vol.57Issue(5)：114-121,8.
复方羟氯扎胺混悬液对藏羊肝片吸虫和线虫的驱虫效果
Clinical efficacy evaluation of compound oxyclozanide suspension on liver fluke and nematode disease in Tibetan sheep
摘要
Abstract
This study was to evaluate the clinical efficacy of compound oxyclozanide suspension on Fasciola hepatica and gastrointestinal nematodes in Tibetan sheep through anthelmintic test of oxyclozanide-levamisole,so as to provide a scientific basis for determining the opti-mal recommended clinical dose of the compound preparation.150 sheep with liver fluke disease and gastrointestinal nematode disease were selected and randomly divided into 5 groups,with 30 sheep in each group.The groups were the low dose(0.125 mL/kg),medium dose(0.25 mL/kg),high dose(0.5 mL/kg),imported drug control(oxyclozanide suspension Levafas Diamond 0.25 mL/kg),and blank con-trol groups.The therapeutic effect of compound hydroxyclozamide suspension was evaluated before and weekly after administration based on clinical conditions,EPG values,egg reduction rate and egg seroconversion rate of the experimental sheep.After the experiment,the weight gain results of sheep showed significant differences(P＜0.05)between the low dose,medium dose,high-dose,and drug control and blank control groups.During the experiment,the weight of the sheep in each experimental group and the imported drug control group increased with time,while the weight of the sheep in the blank control group slightly decreased.After 14 days of administration,the observation of the dew-orming effect on liver fluke showed that the reduction rates of the fecal worm eggs in the low,medium,and high dose groups of compound hydroxyclozamide suspension,the drug control group,and the blank control group were 99.5％,100％,100％,100％,and 0,respectively.The egg conversion rates of each group were 96.7％,100％,100％,100％,and 0,respectively.During the entire trial period,the com-pound hydroxycloxamide suspension had a significant repellent effect on gastrointestinal nematodes such as Osterhabditis,filamentous nema-todes,round nematodes,and twisted blood nematodes.On the 14th day of the administration,the test results showed that the reduction rates of the fecal nematode eggs in the low,medium,and high-dose groups of compound hydroxycloxamide suspension,the drug control group,and the blank control group were 99.6％,100％,100％,100％,and 0,respectively.The egg conversion rates of each group were 93.3％,100％,100％,100％,and 0,respectively.The present results indicated that compound hydroxyclozamide suspension had a significant thera-peutic effect on both Schistosoma hepatica and gastrointestinal nematodes,with a recommended clinical optimal dose of 0.25 mL/kg.关键词
藏羊/肝片吸虫/线虫/复方羟氯扎胺混悬液/药效学Key words
Tibetan sheep/liver fluke/nematodes/compound hydroxyclozamide suspension/pharmacodynamics分类
农业科技引用本文复制引用
姚学强,王娟,李江,周凯仁,翟斌涛,张继瑜,周绪正..复方羟氯扎胺混悬液对藏羊肝片吸虫和线虫的驱虫效果[J].畜牧与兽医,2025,57(5):114-121,8.基金项目
国家重点研发计划项目(2022YFD1602201) （2022YFD1602201）
甘肃省科技计划项目(20JR10RA023) （20JR10RA023）
