物理学报2025，Vol.74Issue(7)：96-103,8.DOI:10.7498/aps.74.20241686
基于光学相干血流造影引导的近红外一区视网膜血氧饱和度测量
Near-infrared band I retinal oximetry guided by optical coherence tomography angiography
摘要
Abstract
Accurate measurement of retinal blood oxygen saturation(SO2)provides valuable early insights into the pathophysiology of ocular diseases such as diabetic retinopathy,glaucoma,and retinal vein occlusion.Visible-light optical coherence tomography(OCT)can directly measure SO2 through spectral fitting,but its application is limited due to the irritability of visible light and its influence on the physiological state of the retina.Near-infrared band Ⅰ(NIR-Ⅰ)causes less ocular stimulation.Even though the hemoglobin absorption effect is weaker in this region,its scattering property is also related to SO2.According to this principle,we propose a novel optical coherence tomography(OCTA)guided NIR-Ⅰ technique for retinal blood oxygen saturation measurement.This method is used to calculate SO2 through calibrating the optical density ratio(ODR)of oxygen-sensitive wavelength(855 nm)to isosbestic wavelength(805 nm).By utilizing the three-dimensional(3D)blood flow maps generated by the OCTA,this technique can automatically identify retinal vessels and surrounding tissue regions,thereby minimizing the errors caused by manual selection.Consequently,the classification accuracy of arteries and veins increases from 82.1％to 96.7％.The calibrated average retinal blood oxygen saturation is 94％±21％for arteries and 56％±13％for veins,which aligns with normal physiological range.The representative result of artery-vein classification is presented in the following figure.This method greatly improves the accuracy and efficiency of measurement,and provides a reliable tool for early diagnosis,disease assessment,and treatment monitoring of ophthalmic diseases,which has broad application prospects.关键词
光学相干血流造影/光学相干层析成像/血氧饱和度/光学密度Key words
optical coherence tomography angiography/optical coherence tomography/blood oxygen saturation/optical density引用本文复制引用
高梦琴,章慧英,孙彬,刘开元,杜持新,李鹏..基于光学相干血流造影引导的近红外一区视网膜血氧饱和度测量[J].物理学报,2025,74(7):96-103,8.基金项目
浙江省"尖兵""领雁"研发攻关计划(批准号:2023C03089)、国家自然科学基金(批准号:62075189,T2293751,T2293753)和浙江省自然科学基金(批准号:LZ24H120002)资助的课题. Project supported by the"Pioneer"and"Leading Goose" R&D Program of Zhejiang Province,China(Grant No.2023C03089),the National Natural Science Foundation of China(Grant Nos.62075189,T2293751,T2293753),and the Natural Science Foundation of Zhenjiang Province,China(Grant No.LZ24H120002). （批准号:2023C03089）
