临床医学工程2025，Vol.32Issue(4)：431-434,4.DOI:10.3969/j.issn.1674-4659.2025.04.0431
荧光定量PCR检测郑州地区汉族人群MTHFR C677T位点多态性分析
Analysis on the MTHFR C677T Polymorphism in Han Population in Zhengzhou Detected by Fluorescent Quantitative PCR
摘要
Abstract
Objective To understand the genetic background of folate metabolism in the Han population of Zhengzhou through molecular epidemiological analysis of the MTHFR C677T gene polymorphism,and to provide a genetic basis for the scientific guidance of folate supplementation.Methods Fluorescence quantitative PCR was used to genotype the MTHFR C677T locus in 6552 Han individuals from Zhengzhou.Literature was reviewed,and data from Zhengzhou were compared and analyzed with those from other regions in the north and south of China.Results The MTHFR C677T locus in Zhengzhou was predominantly characterized by the CT genotype and T allele,accounting for 46.0％and 62.3％,respectively.The frequency of the TT genotype and T allele in Zhengzhou was only lower than that in Shijiazhuang,but higher than those in southern regions such as Guilin,Zhangzhou,Wenzhou,Xuzhou,Taoyuan,and Nanning,and also significantly higher than those in northern regions including Xinjiang Jichang,Ordos,Qinhuangdao,Beijing,Lanzhou,and Zaozhuang,with statistical differences(P＜0.05).Conclusions The overall risk of folate metabolic disorders is relatively high among the Han population in Zhengzhou.Genetic typing of the MTHFR C677T locus should be conducted for individuals in need,and personalized folic acid supplementation plans should be formulated.关键词
汉族人群/MTHFR C677T/多态性Key words
Han population/MTHFR C677T/Polymorphism分类
预防医学引用本文复制引用
张华,刘敏,袁路,姬亚星,张富青..荧光定量PCR检测郑州地区汉族人群MTHFR C677T位点多态性分析[J].临床医学工程,2025,32(4):431-434,4.基金项目
河南省医学科技攻关计划联合共建项目(项目编号:LHGJ20230759) （项目编号:LHGJ20230759）
