现代畜牧科技Issue(4)：28-31,4.DOI:10.19369/j.cnki.2095-9737.2025.04.009
大鼠吸入酒石酸泰万菌素纳米乳急性毒性研究
Acute Toxicity of Tyvanomycin Tartrate Nanoemulsion Inhaled by Rats
摘要
Abstract
In order to evaluate the safety of Tyvanomycin tartrate nanoemulsion(TAT-NE)when administered by inhalation,the acute toxicity evaluation of TAT-NE in rats was carried out.Under GLP conditions,the minimum dose(Dm)and the maximum dose(Dn)that could make all rats survive after inhalation of TAT-NE were determined by pre-test.Based on this,5 dose groups were set up,with 10 rats in each group and half male and half female,and were administered by inhalation for 7 days.The median lethal dose(LD50)was calculated by Bliss method.The LD50 of TAT-NE inhalation in rats was 1 639.8 mg/kg,and the 95%confidence limit of LD50 was(1 371.5 mg/kg,1 960.7 mg/kg).TAT-NE inhalation is low toxicity and safe for experimental animals.关键词
酒石酸泰万菌素纳米乳/急性毒性/吸入给药/LD50Key words
Tyvanomycin tartrate nanoemulsion/acute toxicity/inhalation administration/LD50分类
畜牧业引用本文复制引用
张述阳,崔祜杰,王宏军..大鼠吸入酒石酸泰万菌素纳米乳急性毒性研究[J].现代畜牧科技,2025,(4):28-31,4.基金项目
辽宁省教育厅科研项目(LJ212410160081) （LJ212410160081）
辽宁省种质创新藏梁于技专项计划项目(2023JH1/10200006) （2023JH1/10200006）
辽宁省科技厅博士启动项目(2023-BSBA-160) （2023-BSBA-160）
