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Integrating transcriptomics,metabolomics,and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats

Lidan Hu Ying Zhang Wunan Huang Yuelin Guan Yue Chen Xue Li Xiangjun Chen Lili Yu Zhongkai Cao Yue Wang Caifeng Zhu Yayu Li Jiazhen Yin Zhichao Ma Xuelin He

药物分析学报（英文）2024，Vol.14Issue(12)：1906-1920,15.

药物分析学报（英文）2024，Vol.14Issue(12)：1906-1920,15.DOI:10.1016/j.jpha.2024.101105

Integrating transcriptomics,metabolomics,and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats

Lidan Hu ¹Ying Zhang ²Wunan Huang ¹Yuelin Guan ¹Yue Chen ³Xue Li ⁴Xiangjun Chen ²Lili Yu ⁵Zhongkai Cao ¹Yue Wang ⁶Caifeng Zhu ⁷Yayu Li ⁷Jiazhen Yin ⁷Zhichao Ma ¹Xuelin He⁸

作者信息

1. Department of Nephrology,The Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou,310003,China
2. Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou,310020,China
3. Department of Urology The Second Hospital of Tianjin Medical University Tianjin Institute of Urolog,Tianjin,300211,China
4. Department of Big Data in Health Science School of Public Health,Zhejiang University School of Medicine,Hangzhou,310058,China
5. Centre for Global Health,Usher Institute,The University of Edinburgh,Edinburgh,EH16 4UX,UK||Department of Big Data in Health Science School of Public Health,Zhejiang University School of Medicine,Hangzhou,310058,China
6. Hubei Normal University Huangshi,Hubei,435002,China
7. Department of Nephrology,Hangzhou TCM Hospital,Hangzhou,310007,China
8. Kidney Disease Center The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310003,china
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摘要

关键词

Diabetic nephropathy/Metabolome/Network pharmacology/Sporoderm-broken spores of Ganoderma/lucidum/Transcriptome

Key words

Diabetic nephropathy/Metabolome/Network pharmacology/Sporoderm-broken spores of Ganoderma/lucidum/Transcriptome

引用本文复制引用

Lidan Hu,Ying Zhang,Wunan Huang,Yuelin Guan,Yue Chen,Xue Li,Xiangjun Chen,Lili Yu,Zhongkai Cao,Yue Wang,Caifeng Zhu,Yayu Li,Jiazhen Yin,Zhichao Ma,Xuelin He..Integrating transcriptomics,metabolomics,and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats[J].药物分析学报（英文）,2024,14(12):1906-1920,15.

基金项目

This work was supported by the National Natural Science Foundation of China(Grant Nos.:32271311 and 82200784 to Lidan Hu).The authors express great appreciation to all former and cur-rent members of Hu's Lab and Chen's Lab,for the insightful con-versation and outstanding contributions of this research.We are also grateful to Yingping Xiao for professional expert in the experimental processes. （Grant Nos.:32271311 and 82200784 to Lidan Hu）

药物分析学报（英文）

ISSN：2095-1779

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