中国病理生理杂志2025，Vol.41Issue(4)：757-765,9.DOI:10.3969/j.issn.1000-4718.2025.04.016
糖尿病治疗的研究进展
Progress in treatment of diabetes mellitus
摘要
Abstract
Diabetes mellitus is the third most prevalent disease worldwide,following cardiovascular diseases and cancer.There is no obvious symptom in the early stage of diabetes mellitus.However,in the middle and late stages,diabetes mellitus may lead to severe clinical complications such as diabetic cardiomyopathy,kidney disease,retinopathy,or neuropathy,the primary causes for diabetes-related deaths.Therefore,the early diagnosis and treatment of diabetes mellitus are of practical significance.Compared with traditional diagnostic methods including fasting blood-glucose and oral glucose tolerance tests,the measurement of glycated hemoglobin serves as a gold standard for evaluating long-term blood glucose control,due to the relative stability of glycated hemoglobin under a period of dietary and daily practice.Ear-ly treatment of diabetes mellitus may significantly improve the prognosis of patients and enhance the overall therapeutic out-come.Diet control,physical exercise,medication,as well as psychological and social supports are critical for the treat-ment of diabetes mellitus.To date,the therapeutic methods for diabetes mellitus have been constantly enriching,along with promoted drug design and development.Some emerging technologies,such as therapies using antibodies or stem cells,have been applied to treat diabetes mellitus.Hereby the latest progress in the prevention and treatment of diabetes mellitus was comprehensively reviewed,and the application of antibodies was discussed,which may provide insights into the research and development of antibody drugs for chronic human diseases including diabetes mellitus.关键词
糖尿病/抗糖尿病药/抗体/干细胞Key words
diabetes mellitus/antidiabetics/antibody/stem cells分类
医药卫生引用本文复制引用
陈玉磊,雷雯惠,钟宁,陈巧钦,张凌晶,金腾川,曹敏杰..糖尿病治疗的研究进展[J].中国病理生理杂志,2025,41(4):757-765,9.基金项目
福建省自然科学基金资助项目(No.2021J01838) （No.2021J01838）
国家重点研发计划项目(No.2018YFD0901004) （No.2018YFD0901004）
