中国病理生理杂志2025，Vol.41Issue(4)：775-782,8.DOI:10.3969/j.issn.1000-4718.2025.04.018
RSK2在肿瘤发生发展中作用及其抑制剂的研究进展
Recent advances in role of RSK2 in tumorigenesis and its inhibitors
摘要
Abstract
Ribosomal S6 kinase 2(RSK2),an important member of the RSK family,is involved in cell prolifera-tion,transformation,apoptosis,and the cell cycle.It plays a pivotal role in the development and progression of various tu-mors,making it a promising target for anticancer drug development.To date,there is a notable paucity of effective inhibi-tors,with only one compound,PMD-026,having advanced to the clinical stage of testing.Earlier studies have suggested that RSK2 was regulated exclusively by MAPK,however recent research has shown that AKT1 also activates RSK2.This article provides an in-depth review of the structural and functional characteristics of the RSK2 protein,its signal transduc-tion pathways,and the relationship between RSK2 and tumor development and progression.We also reviews the status of current research and the challenges associated with developing inhibitors that target different sites of RSK2.The objective was to provide valuable insights for the advancement of RSK2 inhibitors.关键词
核糖体S6激酶2/信号通路/肿瘤/抑制剂Key words
ribosomal S6 kinase 2/signalling pathway/tumor/inhibitor分类
基础医学引用本文复制引用
李海啸,艾元宝,刘森..RSK2在肿瘤发生发展中作用及其抑制剂的研究进展[J].中国病理生理杂志,2025,41(4):775-782,8.基金项目
国家自然科学基金资助项目(No.31971150) （No.31971150）
湖北省创新群体项目(No.2024AFA014) （No.2024AFA014）
湖北省杰出青年基金资助项目(No.2019CFA069) （No.2019CFA069）
