中国病理生理杂志2025，Vol.41Issue(4)：809-815,7.DOI:10.3969/j.issn.1000-4718.2025.04.023
中药调控铁死亡在血液系统恶性肿瘤中作用的研究进展
Progress in role of traditional Chinese medicine regulating ferroptosis in hematological malignancies
摘要
Abstract
Hematologic malignancies arise from hematopoietic or immune system tissues and are characterized by abnormal cellular growth.Ferroptosis,a newly recognized form of cell death,is driven by mechanisms such as iron me-tabolism,oxidative defense,and lipid peroxidation.Increasing evidence has highlighted a significant link between ferrop-tosis and various hematologic cancers.Traditional Chinese medicine(TCM)has shown particular promise in the treatment of these cancers,offering unique therapeutic approaches.This article explores the role of ferroptosis modulation in hemato-logic malignancies and reviews the current understanding of how TCM's bioactive compounds and monomers exert their ef-fects in managing hematologic cancers,including leukemia,lymphoma,and multiple myeloma,through the induction of ferroptosis.The objective is to provide insight into potential strategies for targeting ferroptosis as a treatment approach for these malignancies.关键词
铁死亡/血液系统肿瘤/中药/信号通路Key words
ferroptosis/hematologic tumors/traditional Chinese medicine/signaling pathways分类
基础医学引用本文复制引用
魏雨欣,韩炯萍,杨益凡,封蔚莹..中药调控铁死亡在血液系统恶性肿瘤中作用的研究进展[J].中国病理生理杂志,2025,41(4):809-815,7.基金项目
浙江省自然科学基金资助项目(No.LBY23H080002) （No.LBY23H080002）
浙江省医药卫生科技计划项目(No.2023KY348) （No.2023KY348）
浙江省卫生高层次人才-创新人才(浙卫办[2022]32号) （浙卫办[2022]32号）
