医学新知2025，Vol.35Issue(4)：367-375,9.DOI:10.12173/j.issn.1004-5511.202501058
基于血浆代谢组学探究神经酰胺与盐敏感性高血压的因果关联
Causal association between ceramide and salt sensitive hypertension based on plasma metabolomics
摘要
Abstract
Objective To investigate the association and causal relationship between plasma metabolites and salt sensitive hypertension(SSH)using association analysis and Mendelian randomization(MR).Methods Based on the baseline survey data from the System Epidemiology Study on Salt Sensitivity of Blood Pressure(EpiSS),60 participants were selected for untargeted metabolomics and whole-genome genotyping.Multivariable Logistic regression analysis was conducted to explore the association between plasma metabolites and SSH.One-sample and two-sample MR analyses and sensitivity analysis were performed to assess the causal relationship between metabolites and SSH.Results A total of 970 metabolites were measured,73 of which showed a statistically significant association with SSH(P＜0.05).After false discovery rate(FDR)correction,ceramide Cer(d34:0)and Cer(d40:1)remained significantly positively associated with SSH,with OR(95％CI)of 1.55(1.36,1.76)and 2.19(1.66,2.91),respectively.The one-sample MR analysis revealed a causal relationship between Cer(d40:1)and SSH,with both simple genetic risk score(GRS)[OR=2.470,95％CI(1.887,3.234)]and weighted GRS[OR=3.362,95％CI(1.303,8.674)].Two-sample MR analysis did not find a causal relationship between Cer(d34:0)and Cer(d40:1)and SSH(P＞0.05).Conclusion This study identified plasma metabolites Cer(d34:0)and Cer(d40:1)as potential risk factors for SSH,with MR results further supporting a causal relationship between Cer(d40:1)and SSH.These findings provide new evidence for early screening and etiological research of SSH.关键词
血浆代谢物/盐敏感性高血压/代谢组学/孟德尔随机化Key words
Plasma metabolites/Salt sensitive hypertension/Metabolomics/Mendelian randomization分类
临床医学引用本文复制引用
杨晓俊,张博闻,李博雅,温馥源,屈艾彬,姚昕玥,张玲..基于血浆代谢组学探究神经酰胺与盐敏感性高血压的因果关联[J].医学新知,2025,35(4):367-375,9.基金项目
国家自然科学基金面上项目(82273708) （82273708）
